Richard A. Paulson - 06 May 2025 Form 4 Insider Report for Karyopharm Therapeutics Inc. (KPTI)

Role: President and CEO, Director
Signature: /s/Nancy Smith as Attorney-in-Fact for Richard Paulson
Issuer symbol: KPTI
Transactions as of: 06 May 2025
Net transactions value: -$1,680
Form type: 4
Filing time: 07 May 2025, 17:03:41 UTC
Previous filing: 07 Apr 2025
Next filing: 03 Jun 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Paulson Richard A.	President and CEO, Director	C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE, NEWTON	/s/Nancy Smith as Attorney-in-Fact for Richard Paulson	07 May 2025	0001804460

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	KPTI	Common Stock	Sale	$1,680	-236	-0.29%	$7.12	82,503	06 May 2025	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on June 10, 2021, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person.