Siren, L.L.C. - Jul 25, 2024 Form 3 Insider Report for LEXICON PHARMACEUTICALS, INC. (LXRX)

Role: Director, 10%+ Owner
Signature: INVUS GLOBAL MANAGEMENT, LLC, By: /s/ Raymond Debbane, Name: Raymond Debbane Title: President
Stock symbol: LXRX
Transactions as of: Jul 25, 2024
Transactions value $: $0
Form type: 3
Date filed: 7/29/2024, 05:31 PM

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	LXRX	Common Stock						3.52M	Jul 25, 2024	See Footnotes	F1, F2, F4
holding	LXRX	Common Stock						35.4M	Jul 25, 2024	See Footnotes	F1, F3, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	On July 25, 2024, in connection with a reorganization, Invus Global Management, LLC replaced the Geneva branch of Artal International S.C.A. as the managing member of Invus Public Equities Advisors, LLC and Invus Global Management, LLC replaced Artal International S.C.A. as the managing member of Invus Advisors, L.L.C. As a result of the reorganization, Invus Global Management, LLC as the managing member of Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C.; Siren, L.L.C. as the managing member of Invus Global Management, LLC; and Mr. Raymond Debbane as the managing member of Siren, L.L.C. may now be deemed to beneficially own the securities beneficially owned by Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C.
F2	The common stock, $0.001 par value per share (the "Common Stock") is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The managing member of Invus Public Equities Advisors, LLC is Invus Global Management, LLC. The managing member of Invus Global Management, LLC is Siren, L.L.C. The managing member of Siren, L.L.C. is Mr. Raymond Debbane.
F3	The Common Stock is held directly by Invus, L.P. The general partner of Invus, L.P. is Invus Advisors, L.L.C. The managing member of Invus Advisors, L.L.C. is Invus Global Management, LLC. The managing member of Invus Global Management, LLC. is Siren, L.L.C. The managing member of Siren, L.L.C. is Mr. Raymond Debbane.
F4	Each of the Reporting Persons (other than to the extent it directly holds securities reported herein), disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

Remarks:

Artal International S.C.A. directly holds 136,180,481 shares of Common Stock which securities are reported on a separate Form 4. For purposes of Section 16 of the Exchange Act, the Reporting Persons may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.