| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | Director | 601 LEXINGTON AVENUE, 54TH FLOOR, NEW YORK | /s/ Carl L. Gordon, Member of OrbiMed Advisors LLC | 12 Aug 2025 | 0001055951 |
| OrbiMed Capital GP VI LLC | Director | 601 LEXINGTON AVENUE, 54TH FLOOR, NEW YORK | /s/ Carl L. Gordon, Member of OrbiMed Capital GP VI LLC | 12 Aug 2025 | 0001682115 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | TSBX | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -3.1M | -100% | 0 | 08 Aug 2025 | See Footnote | F1, F2, F3 |
| Id | Content |
|---|---|
| F1 | Disposed of pursuant to the terms of the Agreement and Plan of Merger, dated June 26, 2025, by and among the Issuer, XOMA Royalty Corporation ("Purchaser") and XRA 3 Corp., a wholly-owned subsidiary of Purchaser, pursuant to which Purchaser completed a cash tender offer for all outstanding shares of common stock of the Issuer for (i) $0.34 per share in cash, payable subject to any applicable tax withholding and without interest, plus (ii) one non-transferable contractual contingent value right per share, payable subject to any applicable tax withholding and without interest. |
| F2 | These securities are held of record by OrbiMed Private Investments VI, LP ("OPI VI"). OrbiMed Capital GP VI LLC ("GP VI") is the general partner of OPI VI, and OrbiMed Advisors LLC ("OrbiMed Advisors") is the managing member of GP VI. By virtue of such relationships, GP VI and OrbiMed Advisors may be deemed to have voting power and investment power over the securities held by OPI VI and, as a result, may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the securities held by OPI VI. |
| F3 | This report on Form 4 is jointly filed by OrbiMed Advisors and GP VI. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of his or its pecuniary interest therein, if any. OrbiMed Advisors has designated a representative, Rishi Gupta ("Gupta"), an employee of OrbiMed Advisors, to serve on the Issuer's board of directors. This report shall not be deemed an admission that any of the Reporting Persons or Gupta is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose. |