Joshua L. Smiley - 10 Sep 2025 Form 4 Insider Report for Zai Lab Ltd (ZLAB)

Role: President and Chief Operating Officer
Signature: /s/ Bruce Blefeld, Attorney-in-Fact
Issuer symbol: ZLAB
Transactions as of: 10 Sep 2025
Net transactions value: +$289,100
Form type: 4
Filing time: 12 Sep 2025, 16:32:44 UTC
Previous filing: 19 Aug 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Smiley Joshua L	President and Chief Operating Officer	C/O ZAI LAB LIMITED, 314 MAIN STREET, 4TH FLOOR, SUITE 100, CAMBRIDGE	/s/ Bruce Blefeld, Attorney-in-Fact	12 Sep 2025	0001725189

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ZLAB	American Depositary Shares	Purchase	$289,100	+10,000	+13%	$28.91	86,604	10 Sep 2025	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.
F2	The sales by the Reporting Person on August 18, 2025 (reported on the Form 4 filed on August 19, 2025) and on April 2, 2025 (reported on the Form 4 filed on April 3, 2025) of an aggregate 10,000 ADSs were matchable under Section 16(b) of the Exchange Act with the purchase by the Reporting Person of 10,000 ADSs on September 10, 2025 (reported herein). The Reporting Person has agreed to deliver a payment to the Issuer in the amount of $72,111.22, which represents the full amount of the profit realized in connection with these short-swing transactions under Section 16(b) of the Exchange Act.

Content

Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs.

The sales by the Reporting Person on August 18, 2025 (reported on the Form 4 filed on August 19, 2025) and on April 2, 2025 (reported on the Form 4 filed on April 3, 2025) of an aggregate 10,000 ADSs were matchable under Section 16(b) of the Exchange Act with the purchase by the Reporting Person of 10,000 ADSs on September 10, 2025 (reported herein). The Reporting Person has agreed to deliver a payment to the Issuer in the amount of $72,111.22, which represents the full amount of the profit realized in connection with these short-swing transactions under Section 16(b) of the Exchange Act.

Remarks:

President and Chief Operating Officer