| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Kewalramani Reshma | CEO & President, Director | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 26 Feb 2026 | 0001735944 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $2,416,333 | -4,981 | -3.5% | $485.11 | 138,278 | 24 Feb 2026 | Direct |