| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| WAGNER CHARLES F JR | EVP, CO & FO | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 18 Feb 2026 | 0001223348 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $2,226,624 | -4,565 | -9.5% | $487.76 | 43,715 | 13 Feb 2026 | Direct |