| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| WAGNER CHARLES F JR | EVP, CO & FO | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 12 Feb 2026 | 0001223348 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $1,426,308 | -3,045 | -5.9% | $468.41 | 48,280 | 10 Feb 2026 | Direct |