Joseph T. Baroldi - 03 Mar 2026 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role
EVP, Chief Business Officer
Signature
By: Patrick R. O'Neil, attorney-in-fact For: Joseph T. Baroldi
Issuer symbol
IONS
Transactions as of
03 Mar 2026
Net transactions value
-$530,987
Form type
4
Filing time
05 Mar 2026, 18:13:53 UTC
Previous filing
02 Feb 2026
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Baroldi Joseph EVP, Chief Business Officer 2855 GAZELLE COURT, CARLSBAD By: Patrick R. O'Neil, attorney-in-fact For: Joseph T. Baroldi 05 Mar 2026 0001813775

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction IONS Common Stock Sale $325,059 -4,096 -9% $79.36 41,317 03 Mar 2026 Direct F1
transaction IONS Common Stock Options Exercise +820 +17% $56.78* 5,592 03 Mar 2026 by Spouse
transaction IONS Common Stock Options Exercise +879 +16% $32.60* 6,471 03 Mar 2026 by Spouse
transaction IONS Common Stock Sale $167,892 -2,088 -32% $80.41 4,383 03 Mar 2026 by Spouse F2, F3
transaction IONS Common Stock Sale $2,916 -36 -0.82% $81.01 4,347 03 Mar 2026 by Spouse F2
transaction IONS Common Stock Options Exercise +238 +5.5% $56.78* 4,585 04 Mar 2026 by Spouse
transaction IONS Common Stock Sale $19,040 -238 -5.2% $80.00 4,347 04 Mar 2026 by Spouse F2
transaction IONS Common Stock Options Exercise +201 +4.6% $32.60* 4,548 04 Mar 2026 by Spouse
transaction IONS Common Stock Sale $16,080 -201 -4.4% $80.00 4,347 04 Mar 2026 by Spouse F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction IONS Non-Qualified Stock Option (right to buy) Options Exercise -879 -31% $0.000000* 1,970 03 Mar 2026 Common Stock 879 $32.60 by Spouse
transaction IONS Non-Qualified Stock Option (right to buy) Options Exercise -201 -10% $0.000000* 1,769 04 Mar 2026 Common Stock 201 $32.60 by Spouse
transaction IONS Non-Qualified Stock Option (right to buy) Options Exercise -820 -17% $0.000000* 4,104 03 Mar 2026 Common Stock 820 $56.78 by Spouse
transaction IONS Non-Qualified Stock Option (right to buy) Options Exercise -238 -5.8% $0.000000* 3,866 04 Mar 2026 Common Stock 238 $56.78 by Spouse
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 25, 2025.
F2 Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting persons spouse on November 25, 2025.
F3 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.00 to $80.94 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.