| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| O'NEIL PATRICK R. | EVP CLO & General Counsel | 2855 GAZELLE COURT, CARLSBAD | Patrick R. O'Neil | 03 Mar 2026 | 0001564926 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Other | $18,374 | +376 | +0.52% | $48.87 | 72,359 | 27 Feb 2026 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on February 27, 2026. These shares may not be sold until August 27, 2026. |