| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Monia Brett P | Chief Executive Officer, Director | 2855 GAZELLE COURT, CARLSBAD | By: Patrick R. O'Neil, attorney-in-fact For: Brett P. Monia | 03 Mar 2026 | 0001537529 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Other | $23,651 | +484 | +0.19% | $48.87 | 254,981 | 27 Feb 2026 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on February 27, 2026. These shares may not be sold until August 27, 2026. |