| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Birchler Brian | EVP, Corp and Development Ops | 2855 GAZELLE COURT, CARLSBAD | By: Patrick R. O'Neil, attorney-in-fact For: Brian Birchler | 03 Mar 2026 | 0001970151 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Other | $17,152 | +351 | +0.53% | $48.87 | 66,598 | 27 Feb 2026 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on February 27, 2026. These shares may not be sold until August 27, 2026. |