C. Frank Bennett - 02 Feb 2026 Form 4/A - Amendment Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: EVP, Chief Scientific Officer
Signature: By: Patrick R. O'Neil, attorney-in-fact For: C. Frank Bennett
Issuer symbol: IONS
Transactions as of: 02 Feb 2026
Net transactions value: $0
Form type: 4/A - Amendment
Filing time: 13 Feb 2026, 19:40:36 UTC
Date Of Original Report: 04 Feb 2026
Previous filing: 02 Feb 2026
Next filing: 03 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
BENNETT C FRANK	EVP, Chief Scientific Officer	2855 GAZELLE COURT, CARLSBAD	By: Patrick R. O'Neil, attorney-in-fact For: C. Frank Bennett	13 Feb 2026	0001073387

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Other	$0	0	0%	$0.000000	100,293	02 Feb 2026	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	On February 4, 2026, the reporting person filed a Form 4 reporting the sale of 20,000 shares of common stock and the exercise of 65,089 stock options, which transactions were executed in error and subsequently reversed on February 12, 2026. Shares beneficially owned by the reporting person as of February 12, 2026 is 100,293.