Holly B. Kordasiewicz - 21 Dec 2025 Form 3 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role
EVP, Chief Development Officer
Signature
By: Patrick R. O'Neil, attorney-in-fact For: Holly Kordasiewicz
Issuer symbol
IONS
Transactions as of
21 Dec 2025
Net transactions value
$0
Form type
3
Filing time
06 Jan 2026, 17:34:53 UTC
Next filing
20 Jan 2026
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Kordasiewicz Holly B. EVP, Chief Development Officer 2855 GAZELLE COURT, CARLSBAD By: Patrick R. O'Neil, attorney-in-fact For: Holly Kordasiewicz 05 Jan 2026 0002102721

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
holding IONS Common Stock 7,740 21 Dec 2025 Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
holding IONS Non-Qualified Stock Option (right to buy) 21 Dec 2025 Common Stock 12,000 $32.60 Direct
holding IONS Non-Qualified Stock Option (right to buy) 21 Dec 2025 Common Stock 10,000 $34.69 Direct
holding IONS Non-Qualified Stock Option (right to buy) 21 Dec 2025 Common Stock 11,500 $37.58 Direct
holding IONS Non-Qualified Stock Option (right to buy) 21 Dec 2025 Common Stock 19,800 $52.87 Direct
holding IONS Non-Qualified Stock Option (right to buy) 21 Dec 2025 Common Stock 19,895 $56.78 Direct
holding IONS Non-Qualified Stock Option (right to buy) 21 Dec 2025 Common Stock 28,951 $60.89 Direct
holding IONS Restricted Stock Unit 21 Dec 2025 Common Stock 31,949 $0.000000 Direct F1, F2
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 Each restricted stock unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
F2 Grants to reporting person of restricted stock units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan on January 15, 2022, January 15, 2023, January 15, 2024, and January 15, 2025. The restricted stock units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.