| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| WENDER JOSEPH H | Director | 2855 GAZELLE COURT, CARLSBAD | By: Patrick R. O'Neil, attorney-in-fact For: Joseph H. Wender | 19 Nov 2025 | 0001073384 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Options Exercise | $390,720 | +16,000 | $24.42 | 16,000 | 18 Nov 2025 | Direct | F1 | |
| holding | IONS | Common Stock | 64,035 | 18 Nov 2025 | by Trust |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Non-Qualified Stock Option (right to buy) | Options Exercise | $0 | -16,000 | -100% | $0.000000 | 0 | 18 Nov 2025 | Common Stock | 16,000 | $24.42 | Direct |
| Id | Content |
|---|---|
| F1 | Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/2026. |