| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| HERMAN JOAN E | Director | 2855 GAZELLE COURT, CARLSBAD | By: Patrick R. O'Neil, attorney-in-fact For: Joan E. Herman | 20 Nov 2025 | 0001248398 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Options Exercise | $480,600 | +12,000 | +26% | $40.05 | 58,086 | 19 Nov 2025 | Direct | |
| transaction | IONS | Common Stock | Sale | $865,590 | -12,000 | -21% | $72.13 | 46,086 | 19 Nov 2025 | Direct | F1 |
| transaction | IONS | Common Stock | Options Exercise | $2,044,800 | +32,000 | +69% | $63.90 | 78,086 | 19 Nov 2025 | Direct | |
| transaction | IONS | Common Stock | Sale | $2,308,240 | -32,000 | -41% | $72.13 | 46,086 | 19 Nov 2025 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Non-Qualified Stock Option (right to buy) | Options Exercise | $0 | -12,000 | -100% | $0.000000 | 0 | 19 Nov 2025 | Common Stock | 12,000 | $40.05 | Direct | |
| transaction | IONS | Non-Qualified Stock Option (right to buy) | Options Exercise | $0 | -32,000 | -100% | $0.000000 | 0 | 19 Nov 2025 | Common Stock | 32,000 | $63.90 | Direct |
| Id | Content |
|---|---|
| F1 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $71.985 to $72.33 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) on this Form 4. |