| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Swayze Eric | EVP Research | 2855 GAZELLE COURT, CARLSBAD | By: Patrick R. O'Neil, attorney-in-fact For: Eric Swayze | 16 Oct 2025 | 0001791058 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Options Exercise | $0 | +125 | +68% | $0.000000 | 309 | 15 Oct 2025 | by Son | F1 |
| transaction | IONS | Common Stock | Sale | $3,902 | -53 | -17% | $73.62 | 256 | 16 Oct 2025 | by Son | F2 |
| holding | IONS | Common Stock | 30,453 | 15 Oct 2025 | Direct |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Restricted Stock Unit | Options Exercise | $0 | -125 | -20% | $0.000000 | 497 | 15 Oct 2025 | Common Stock | 125 | $0.000000 | by Son | F3, F4 |
| Id | Content |
|---|---|
| F1 | Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award. |
| F2 | The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice. |
| F3 | Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. |
| F4 | Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. |