Brian Birchler - 14 Oct 2025 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role
EVP, Corp and Development Ops
Signature
By: Patrick R. O'Neil, attorney-in-fact For: Brian Birchler
Issuer symbol
IONS
Transactions as of
14 Oct 2025
Net transactions value
-$438,884
Form type
4
Filing time
16 Oct 2025, 20:15:51 UTC
Previous filing
03 Sep 2025
Next filing
07 Nov 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Birchler Brian EVP, Corp and Development Ops 2855 GAZELLE COURT, CARLSBAD By: Patrick R. O'Neil, attorney-in-fact For: Brian Birchler 16 Oct 2025 0001970151

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction IONS Common Stock Options Exercise $617,011 +11,475 +20% $53.77 68,301 14 Oct 2025 Direct
transaction IONS Common Stock Sale $826,589 -11,475 -17% $72.03 56,826 14 Oct 2025 Direct F1, F2
transaction IONS Common Stock Options Exercise $668,092 +12,425 +22% $53.77 69,251 15 Oct 2025 Direct
transaction IONS Common Stock Sale $897,398 -12,425 -18% $72.23 56,826 15 Oct 2025 Direct F1, F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction IONS Non-Qualified Stock Option (right to buy) Options Exercise $0 -11,475 -48% $0.000000 12,425 14 Oct 2025 Common Stock 11,475 $53.77 Direct
transaction IONS Non-Qualified Stock Option (right to buy) Options Exercise $0 -12,425 -100% $0.000000 0 15 Oct 2025 Common Stock 12,425 $53.77 Direct
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on August 12, 2024.
F2 The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.00 to $72.115, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) of this Form 4.
F3 The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.00 to $72.46, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4.