| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Monia Brett P | Chief Executive Officer, Director | 2855 GAZELLE COURT, CARLSBAD | By: Patrick R. O'Neil, attorney-in-fact For: Brett Monia | 03 Sep 2025 | 0001537529 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | IONS | Common Stock | Other | $5.24K | +189 | +0.11% | $27.71 | 180K | 29 Aug 2025 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 29, 2025. These shares may not be sold until March 2, 2026. |