Brian Birchler - 28 Dec 2023 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: EVP, Corp and Development Ops
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Brian Birchler
Issuer symbol: IONS
Transactions as of: 28 Dec 2023
Net transactions value: -$12,554
Form type: 4
Filing time: 02 Jan 2024, 17:54:26 UTC
Previous filing: 19 Apr 2023
Next filing: 04 Jan 2024
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Options Exercise	$544,410	+11,500	+31%	$47.34	48,028	28 Dec 2023	Direct
transaction	IONS	Common Stock	Tax liability	$556,964	-11,029	-23%	$50.50	36,999	28 Dec 2023	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Non-Qualified Stock Option (right to buy)	Options Exercise	$0	-11,500	-43%	$0.000000	15,482	28 Dec 2023	Common Stock	11,500	$47.34	Direct

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents a "net exercise" of outstanding stock options. The reporting person received 471 shares of common stock on net exercise of option to purchase 11,500 shares of common stock. Pursuant to the terms of the Company's 2011 Equity Incentive Plan, the Company withheld 11,029 shares of common stock underlying the option for payment of the exercise price and tax withholdings using the closing stock price on December 28, 2023 of $50.50.

Content

Represents a "net exercise" of outstanding stock options. The reporting person received 471 shares of common stock on net exercise of option to purchase 11,500 shares of common stock. Pursuant to the terms of the Company's 2011 Equity Incentive Plan, the Company withheld 11,029 shares of common stock underlying the option for payment of the exercise price and tax withholdings using the closing stock price on December 28, 2023 of $50.50.