Michael R. Hayden - Jul 17, 2023 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Director
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Michael R. Hayden
Stock symbol: IONS
Transactions as of: Jul 17, 2023
Transactions value $: $0
Form type: 4
Date filed: 7/19/2023, 06:05 PM
Previous filing: Jul 6, 2023
Next filing: Aug 9, 2023

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Options Exercise	$0	+1.78K	+7.69%	$0.00	24.9K	Jul 17, 2023	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+5.33K	+21.43%	$0.00	30.2K	Jul 17, 2023	Direct	F1
holding	IONS	Common Stock						2K	Jul 17, 2023	by Spouse	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-1.78K	-15.08%	$0.00	10K	Jul 17, 2023	Common Stock	1.78K	$0.00	Direct	F3, F4
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-5.33K	-53.28%	$0.00	4.68K	Jul 17, 2023	Common Stock	5.33K	$0.00	Direct	F3, F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.
F2	These securities are held by Genworks 2 Consulting, Inc. ("Genworks 2"). The Reporting Person's spouse has sole voting and investment power with respect to the shares held by Genworks 2.
F3	Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
F4	Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.
F5	Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.