Spencer R. Berthelsen - Jul 15, 2022 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Director
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Spencer R. Berthelsen
Stock symbol: IONS
Transactions as of: Jul 15, 2022
Transactions value $: $0
Form type: 4
Date filed: 7/19/2022, 07:19 PM
Previous filing: Jul 6, 2022
Next filing: Jun 22, 2023

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Options Exercise	$0	+5.33K	+4.41%	$0.00	126K	Jul 15, 2022	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+2.67K	+2.11%	$0.00	129K	Jul 15, 2022	Direct	F2
holding	IONS	Common Stock						70	Jul 15, 2022	by Daughter	F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-5.33K	-35.3%	$0.00	9.78K	Jul 15, 2022	Common Stock	5.33K	$0.00	Direct	F4, F5
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-2.67K	-27.26%	$0.00	7.11K	Jul 15, 2022	Common Stock	2.67K	$0.00	Direct	F4, F6

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.
F2	Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards.
F3	The reporting person disclaims beneficial ownership of all securities held by his daughter, and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.
F4	Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
F5	Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.
F6	Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.