Spencer R. Berthelsen - 07 Jun 2022 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Director
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Spencer R. Berthelsen
Issuer symbol: IONS
Transactions as of: 07 Jun 2022
Net transactions value: +$145,575
Form type: 4
Filing time: 09 Jun 2022, 17:53:50 UTC
Previous filing: 19 Jul 2021
Next filing: 06 Jul 2022
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Options Exercise	$145,575	+11,250	+10%	$12.94	120,899	07 Jun 2022	Direct	F1
holding	IONS	Common Stock						70	07 Jun 2022	by Daughter	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Non-Qualified Stock Option (right to buy)	Options Exercise	$0	-11,250	-100%	$0.000000^*	0	07 Jun 2022	Common Stock	11,250	$12.94	Direct

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Acquired as a result of exercising a stock option that was scheduled to expire on 7/1/2022.
F2	The reporting person disclaims beneficial ownership of all securities held by his daughter, and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.