Joseph Klein III - 31 Dec 2021 Form 5 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Director
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Joseph Klein III
Issuer symbol: IONS
Transactions as of: 31 Dec 2021
Net transactions value: $0
Form type: 5
Filing time: 14 Feb 2022, 17:19:16 UTC
Previous filing: 19 Jul 2021
Next filing: 06 Jul 2022
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Gift	$0	-6,000	-33%	$0.000000	12,126	30 Nov 2021	Direct	F1
transaction	IONS	Common Stock	Gift	$0	+6,000		$0.000000	6,000	30 Nov 2021	by Trust	F1
holding	IONS	Common Stock						100	31 Dec 2021	by Son	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	-12,000	-100%	$0.000000^*	0	30 Nov 2021	Common Stock	12,000	$24.42	Direct	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	-12,000	-75%	$0.000000	4,000	30 Nov 2021	Common Stock	12,000	$42.88	Direct	F3, F4
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	-16,000	-100%	$0.000000^*	0	30 Nov 2021	Common Stock	16,000	$52.22	Direct	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	-16,000	-100%	$0.000000^*	0	30 Nov 2021	Common Stock	16,000	$57.16	Direct	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	-12,000	-100%	$0.000000^*	0	30 Nov 2021	Common Stock	12,000	$60.20	Direct	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	-8,000	-50%	$0.000000	8,000	30 Nov 2021	Common Stock	8,000	$64.80	Direct	F3, F5
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	+12,000		$0.000000	12,000	30 Nov 2021	Common Stock	12,000	$24.42	by Trust	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	+12,000		$0.000000	12,000	30 Nov 2021	Common Stock	12,000	$42.88	by Trust	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	+16,000		$0.000000	16,000	30 Nov 2021	Common Stock	16,000	$52.22	by Trust	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	+16,000		$0.000000	16,000	30 Nov 2021	Common Stock	16,000	$57.16	by Trust	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	+12,000		$0.000000	12,000	30 Nov 2021	Common Stock	12,000	$60.20	by Trust	F3
transaction	IONS	Non-Qualified Stock Option (right to buy)	Gift	$0	+8,000		$0.000000	8,000	30 Nov 2021	Common Stock	8,000	$64.80	by Trust	F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The reported transaction reflects the gift of shares to trusts for the benefit of the reporting person's three children, of which the reporting person's wife is a trustee.
F2	The reporting person disclaims beneficial ownership of all securities held by his son, and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.
F3	The reported transactions reflect the gift of vested stock options to trusts for the benefit of the reporting person's three children, of which the reporting person's wife is a trustee.
F4	Grant of 7/2/18 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, with the first installment vesting on 7/2/19. The option shall be fully vested and exercisable on 7/2/22. The option was exercisable as to 12,000 shares on 11/30/21.
F5	Grant of 7/1/19 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, with the first installment vesting on 7/1/20. The option shall be fully vested and exercisable on 7/1/23. The option was exercisable as to 8,000 shares on 11/30/21.