Joseph Loscalzo - Jul 15, 2021 Form 4 Insider Report for IONIS PHARMACEUTICALS INC (IONS)

Role: Director, Chairman of Board
Signature: By: Patrick R. O'Neil, attorney-in-fact For: Joseph Loscalzo
Stock symbol: IONS
Transactions as of: Jul 15, 2021
Transactions value $: $0
Form type: 4
Date filed: 7/19/2021, 08:14 PM
Previous filing: Jul 6, 2021
Next filing: Feb 2, 2022

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	IONS	Common Stock	Options Exercise	$0	+5.33K	+30.81%	$0.00	22.6K	Jul 15, 2021	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+889	+3.93%	$0.00	23.5K	Jul 15, 2021	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+666	+2.83%	$0.00	24.2K	Jul 15, 2021	Direct	F1
transaction	IONS	Common Stock	Options Exercise	$0	+1.78K	+7.35%	$0.00	26K	Jul 15, 2021	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-5.33K	-28.92%	$0.00	13.1K	Jul 15, 2021	Common Stock	5.33K	$0.00	Direct	F2, F3
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-889	-6.78%	$0.00	12.2K	Jul 15, 2021	Common Stock	889	$0.00	Direct	F2, F4
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-666	-5.45%	$0.00	11.6K	Jul 15, 2021	Common Stock	666	$0.00	Direct	F2, F4
transaction	IONS	Restricted Stock Unit	Options Exercise	$0	-1.78K	-15.39%	$0.00	9.78K	Jul 15, 2021	Common Stock	1.78K	$0.00	Direct	F2, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.
F2	Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.
F3	Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.
F4	Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.