EcoR1 Capital, LLC

Q4 2025 13F Holdings Report, Options Holdings

Notable people: Oleg Nodelman
Signature - Title: Oleg Nodelman - Manager
Location: San Francisco, CA
Options holdings as of: 31 Dec 2025
Notional value: $13,190,481
Number of holdings: 2
Filing time: 17 Feb 2026, 11:53:55 UTC
Description: All US holdings of this investor are reported in this report.
Previous filing: Q3 2025 - 14 Nov 2025
Stock holdings: Showing options holdings, see here for stock holdings

Sym	Company	Class	Option	Share Change	Activity	* Price $	Shares	Notional Value

Filing 2025 Q4 compared to 2025 Q3 by default. Changes are calculated vs the previous SEC filing.

Compare Q4 2025 to

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.

Person Signing this Report on Behalf of Reporting Manager:

Name	Title	City, State	Date
Oleg Nodelman	Manager	San Francisco, California	11 Feb 2026