BAKER BROS. ADVISORS LP

Holdings History for SPARK THERAPEUTICS INC - COM (ONCE)

Symbol: ONCE
Investment type: Equity / COM

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2019		-0.5%	$0	0	-751,927	-100%		Q4 2019
30 Sep 2019	0.5%	0%	$72,922,000	751,927	0		$96.98	Q3 2019
30 Jun 2019	0.52%	0%	$76,982,000	751,927	0		$102.38	Q2 2019
31 Mar 2019	0.55%	-0.46%	$85,629,000	751,927	-632,203	-46%	$113.88	Q1 2019
31 Dec 2018	0.44%	0%	$54,175,000	1,384,130	0		$39.14	Q4 2018
30 Sep 2018	0.5%	0%	$75,504,000	1,384,130	0		$54.55	Q3 2018
30 Jun 2018	0.86%	0%	$114,551,000	1,384,130	0		$82.76	Q2 2018
31 Mar 2018	0.78%	0%	$92,169,000	1,384,130	0		$66.59	Q1 2018
31 Dec 2017	0.62%	0%	$71,172,000	1,384,130	0		$51.42	Q4 2017
30 Sep 2017	1%	+0.05%	$123,409,000	1,384,130	+65,789	+5%	$89.16	Q3 2017
30 Jun 2017	0.69%	0%	$78,758,000	1,318,341	0		$59.74	Q2 2017
31 Mar 2017	0.58%	0%	$70,320,000	1,318,341	0		$53.34	Q1 2017
31 Dec 2016	0.64%	0%	$65,785,000	1,318,341	0		$49.90	Q4 2016
30 Sep 2016	0.72%	0%	$79,180,000	1,318,341	0		$60.06	Q3 2016
30 Jun 2016	0.71%	+0.03%	$67,407,000	1,318,341	+55,959	+4.4%	$51.13	Q2 2016
31 Mar 2016	0.39%	0%	$37,253,000	1,262,382	0		$29.51	Q1 2016
31 Dec 2015	0.47%	0%	$57,199,000	1,262,382	0		$45.31	Q4 2015
30 Sep 2015	0.49%	0%	$52,679,000	1,262,382	0		$41.73	Q3 2015
30 Jun 2015	0.67%	-0.03%	$76,084,000	1,262,382	-65,069	-4.9%	$60.27	Q2 2015
31 Mar 2015	0.86%	+0.86%	$102,878,000	1,327,451	+1,327,451	NEW	$77.50	Q1 2015

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.