TWO SIGMA INVESTMENTS, LP

Holdings History for Annovis Bio, Inc. - Common Stock, par value $0.0001 per share (ANVS)

Symbol: ANVS on NYSE
Investment type: Equity / Common Stock, par value $0.0001 per share

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025	0%	+0%	$1,909,356	551,837	+551,837	NEW	$3.46	Q4 2025
30 Jun 2025		-0%	$0	0	-166,219	-100%	$2.60	Q2 2025
31 Mar 2025	0%	+0%	$249,329	166,219	+155,296	+1400%	$1.50	Q1 2025
31 Dec 2024	0%	+0%	$54,943	10,923	+10,923	NEW	$5.03	Q4 2024
31 Mar 2022		-0%	$0	0	-51,747	-100%	$2.60	Q1 2022
31 Dec 2021	0%	-0%	$910,000	51,747	-45,819	-47%	$17.59	Q4 2021
30 Sep 2021	0.01%	+0.01%	$3,098,000	97,566	+97,566	NEW	$31.75	Q3 2021

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.