ESSEX INVESTMENT MANAGEMENT CO LLC

Holdings History for OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK)

Symbol: OPK on Nasdaq
Investment type: Equity / Common Stock, par value $0.01 per share

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Mar 2021		-0.05%	$0	0	-95,839	-100%	$1.24	Q1 2021
31 Dec 2020	0.05%	-0.01%	$379,000	95,839	-29,161	-23%	$3.95	Q4 2020
30 Sep 2020	0.07%	+0.07%	$461,000	125,000	+125,000	NEW	$3.69	Q3 2020
31 Dec 2018		-0.12%	$0	0	-285,700	-100%	$1.24	Q4 2018
30 Sep 2018	0.12%	0%	$989,000	285,700	0		$3.46	Q3 2018
30 Jun 2018	0.17%	+0.01%	$1,343,000	285,700	+9,697	+3.5%	$4.70	Q2 2018
31 Mar 2018	0.12%	+0.12%	$875,000	276,003	+276,003	NEW	$3.17	Q1 2018
31 Dec 2017		-0.24%	$0	0	-253,484	-100%	$1.24	Q4 2017
30 Sep 2017	0.24%	-0.01%	$1,739,000	253,484	-13,465	-5%	$6.86	Q3 2017
30 Jun 2017	0.25%	+0%	$1,757,000	266,949	+2,153	+0.81%	$6.58	Q2 2017
31 Mar 2017	0.33%	-0.02%	$2,118,000	264,796	-15,100	-5.4%	$8.00	Q1 2017
31 Dec 2016	0.43%	+0.04%	$2,603,000	279,896	+25,800	+10%	$9.30	Q4 2016
30 Sep 2016	0.43%	-0.21%	$2,691,000	254,096	-123,400	-33%	$10.59	Q3 2016
30 Jun 2016	0.59%	+0.06%	$3,526,000	377,496	+41,607	+12%	$9.34	Q2 2016
31 Mar 2016	0.6%	+0.03%	$3,490,000	335,889	+15,000	+4.7%	$10.39	Q1 2016
31 Dec 2015	0.5%	+0.02%	$3,225,000	320,889	+10,000	+3.2%	$10.05	Q4 2015
30 Sep 2015	0.43%	+0.07%	$2,615,000	310,889	+52,744	+20%	$8.41	Q3 2015
30 Jun 2015	0.63%	-0.53%	$4,151,000	258,145	-217,148	-46%	$16.08	Q2 2015
31 Mar 2015	0.94%	+0.17%	$6,735,000	475,293	+85,000	+22%	$14.17	Q1 2015
31 Dec 2014	0.57%	0%	$3,899,000	390,293	0		$9.99	Q4 2014
30 Sep 2014	0.51%	+0.09%	$3,321,000	390,293	+67,500	+21%	$8.51	Q3 2014
30 Jun 2014	0.42%	0%	$2,853,000	322,793	0		$8.84	Q2 2014
31 Mar 2014	0.44%	+0.12%	$3,008,000	322,793	+91,693	+40%	$9.32	Q1 2014
31 Dec 2013	0.28%	0%	$1,950,000	231,100	0		$8.44	Q4 2013

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.