| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 6.2% | +22% | $440,035,446 | +$105,420,791 | 4,673,770 | +32% | Paradigm BioCapital Advisors LP | 30 Sep 2025 |
| Commodore Capital LP | 4.7% | -13% | $192,112,500 | -$12,262,500 | 3,525,000 | -6% | Commodore Capital LP | 30 Jun 2025 |
| FMR LLC | 3.7% | $262,013,365 | 2,782,935 | FMR LLC | 30 Sep 2025 | |||
| RTW INVESTMENTS, LP | 2.7% | $190,679,830 | 2,025,277 | RTW Investments, LP | 30 Sep 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 0.6% | -88% | $43,223,041 | -$307,647,929 | 459,087 | -88% | Wellington Management Group LLP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 5.8% | 4,373,770 | +2.1% | 12% | $411,790,446 |
| Avoro Capital Advisors LLC | 4.7% | 3,542,500 | +12% | 4.3% | $333,526,375 |
| Commodore Capital LP | 4.6% | 3,525,000 | 0% | 16% | $331,878,750 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4% | 3,046,916 | -10% | 4.4% | $286,867,141 |
| HBK INVESTMENTS L P | 3.8% | 2,850,000 | 4% | $268,327,500 | |
| FMR LLC | 3.7% | 2,810,935 | -62% | 0.01% | $264,649,564 |
| BlackRock, Inc. | 2.9% | 2,172,015 | +107% | 0% | $204,495,213 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2.8% | 2,132,489 | +4.4% | 0.84% | $200,773,839 |
| RTW INVESTMENTS, LP | 2.7% | 2,025,277 | -49% | 2.3% | $190,679,830 |
| Woodline Partners LP | 2.2% | 1,674,167 | +8.5% | 0.74% | $157,622,823 |
| GLAZER CAPITAL, LLC | 2.1% | 1,619,372 | 5.1% | $152,464,000 | |
| Lynx1 Capital Management LP | 2% | 1,534,141 | -2.2% | 29% | $144,439,375 |
| PERCEPTIVE ADVISORS LLC | 1.8% | 1,353,093 | +91% | 3.7% | $127,393,706 |
| FEDERATED HERMES, INC. | 1.6% | 1,249,162 | -18% | 0.21% | $117,608,602 |
| ALLIANCEBERNSTEIN L.P. | 1.6% | 1,196,325 | +8.5% | 0.04% | $112,633,999 |
| GOLDMAN SACHS GROUP INC | 1.6% | 1,195,408 | +1021% | 0.02% | $112,547,664 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.4% | 1,087,143 | -52% | 0.01% | $102,355,000 |
| KRYGER CAPITAL Ltd | 1.4% | 1,053,500 | 11% | $99,187,025 | |
| Magnetar Financial LLC | 1.4% | 1,045,209 | 0.6% | $98,406,427 | |
| Pentwater Capital Management LP | 1.3% | 970,000 | 0.82% | $91,325,500 | |
| AMERIPRISE FINANCIAL INC | 1.2% | 898,822 | -21% | 0.02% | $84,624,258 |
| TIG Advisors, LLC | 1.1% | 868,145 | 5% | $81,735,852 | |
| ALPINE ASSOCIATES MANAGEMENT INC. | 1.1% | 835,600 | 4.8% | $78,671,739 | |
| JPMORGAN CHASE & CO | 1% | 756,013 | +9.4% | 0% | $71,178,624 |
| NOVO HOLDINGS A/S | 0.99% | 750,000 | 0% | 4.6% | $70,612,500 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 0 | $0 | -$4,989,877 | $96.63 | 0 |
| 2025 Q3 | 69,045,071 | $6,500,256,699 | -$237,056,971 | $94.15 | 260 |
| 2025 Q2 | 74,805,584 | $3,934,869,962 | +$216,360,414 | $52.60 | 200 |
| 2025 Q1 | 70,836,661 | $2,982,592,220 | +$29,910,241 | $42.09 | 185 |
| 2024 Q4 | 70,372,416 | $2,959,108,162 | -$77,769,391 | $42.05 | 190 |
| 2024 Q3 | 69,023,165 | $3,453,000,438 | +$64,077,831 | $49.96 | 186 |
| 2024 Q2 | 66,505,364 | $3,935,120,138 | +$944,081,758 | $59.17 | 176 |
| 2024 Q1 | 51,233,583 | $2,306,963,444 | +$30,953,081 | $45.03 | 155 |
| 2023 Q4 | 51,213,294 | $1,408,520,114 | +$91,147,769 | $27.50 | 128 |
| 2023 Q3 | 47,491,302 | $1,119,891,239 | +$142,312,228 | $23.58 | 112 |
| 2023 Q2 | 41,257,480 | $1,086,320,462 | +$132,534,899 | $26.33 | 111 |
| 2023 Q1 | 36,522,352 | $671,981,883 | +$2,460,096 | $18.40 | 103 |
| 2022 Q4 | 36,513,596 | $564,873,025 | -$17,806,534 | $15.47 | 91 |
| 2022 Q3 | 34,387,134 | $688,765,575 | -$18,872,808 | $20.03 | 100 |
| 2022 Q2 | 35,043,797 | $793,382,953 | +$41,956,175 | $22.64 | 93 |
| 2022 Q1 | 33,209,323 | $878,080,617 | -$17,319,721 | $26.44 | 94 |
| 2021 Q4 | 32,999,686 | $1,049,315,646 | +$312,713,905 | $31.80 | 103 |
| 2021 Q3 | 22,166,080 | $487,779,159 | -$93,778,101 | $22.00 | 63 |
| 2021 Q2 | 26,784,956 | $564,348,331 | +$1,605,878 | $21.07 | 66 |
| 2021 Q1 | 26,725,442 | $558,325,760 | +$113,660,788 | $20.89 | 58 |
| 2020 Q4 | 22,046,847 | $386,593,075 | +$58,495,806 | $17.53 | 43 |
| 2020 Q3 | 18,197,336 | $218,401,600 | -$6,778,757 | $12.00 | 41 |
| 2020 Q2 | 18,590,455 | $299,121,000 | +$19,430,635 | $16.09 | 42 |
| 2020 Q1 | 18,005,073 | $217,858,000 | +$1,723,160 | $12.10 | 29 |
| 2019 Q4 | 17,842,709 | $251,227,000 | +$61,139,029 | $14.08 | 37 |
| 2019 Q3 | 11,877,122 | $211,649,000 | +$2,519,436 | $17.82 | 26 |
| 2019 Q2 | 11,830,344 | $173,308,000 | -$426,523 | $14.65 | 26 |
| 2019 Q1 | 11,859,344 | $175,160,000 | -$2,838,143 | $14.77 | 24 |
| 2018 Q4 | 12,071,835 | $169,003,000 | -$3,568,060 | $14.00 | 26 |
| 2018 Q3 | 12,054,339 | $237,947,000 | -$3,669,154 | $19.74 | 29 |
| 2018 Q2 | 12,310,935 | $280,168,000 | +$31,199,716 | $22.76 | 25 |
| 2018 Q1 | 9,796,183 | $181,524,000 | +$38,987,498 | $18.53 | 20 |
| 2017 Q4 | 5,703,167 | $110,530,000 | -$2,557,404 | $19.40 | 16 |
| 2017 Q3 | 5,831,528 | $115,872,000 | -$9,235,916 | $19.87 | 16 |
| 2017 Q2 | 6,307,149 | $99,970,000 | -$1,169,691 | $15.85 | 16 |
| 2017 Q1 | 6,339,526 | $154,589,000 | +$35,982,508 | $24.38 | 22 |
| 2016 Q4 | 4,863,545 | $102,671,000 | +$3,571,943 | $21.11 | 11 |
| 2016 Q3 | 4,695,313 | $78,616,000 | +$190,127 | $16.75 | 12 |
| 2016 Q2 | 4,811,781 | $38,568,000 | +$38,568,000 | $7.99 | 16 |