| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 15% | $345,826,621 | 16,025,330 | Fairmount Funds Management LLC | 23 Oct 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 4.5% | $48,373,931 | 3,575,309 | Venrock Healthcare Capital Partners III, L.P. | 31 Dec 2024 | |||
| Commodore Capital LP | 3.9% | -28% | $69,056,000 | -$23,738,000 | 3,200,000 | -26% | Commodore Capital LP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 15% | 12,249,355 | +0.09% | 0.01% | $264,341,081 |
| BlackRock, Inc. | 6.6% | 5,428,521 | -1.7% | 0% | $117,147,485 |
| Deep Track Capital, LP | 6.6% | 5,380,449 | 0% | 3.2% | $116,110,089 |
| Kynam Capital Management, LP | 5.4% | 4,427,927 | 0% | 7.1% | $95,554,665 |
| VANGUARD GROUP INC | 5.3% | 4,331,983 | -3.9% | 0% | $93,484,193 |
| VR ADVISER, LLC | 4.7% | 3,882,709 | 0% | 4.7% | $83,788,860 |
| Fairmount Funds Management LLC | 4.2% | 3,459,913 | 0% | 6.7% | $74,664,923 |
| Commodore Capital LP | 3.9% | 3,200,000 | -34% | 3.4% | $69,056,000 |
| TANG CAPITAL MANAGEMENT LLC | 3.5% | 2,842,925 | 0% | 2.4% | $61,350,322 |
| Paradigm Biocapital Advisors LP | 3.2% | 2,609,353 | -4.8% | 1.7% | $56,309,838 |
| STATE STREET CORP | 3.1% | 2,554,166 | +0.03% | 0% | $55,118,902 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.9% | 2,418,104 | -16% | 0.01% | $52,184,000 |
| NOVO HOLDINGS A/S | 2.9% | 2,380,000 | 0% | 3.3% | $51,360,400 |
| MAVERICK CAPITAL LTD | 2.7% | 2,212,701 | -2% | 0.64% | $47,750,088 |
| Eversept Partners, LP | 2.3% | 1,924,306 | +1.1% | 3.2% | $41,526,523 |
| ALLIANCEBERNSTEIN L.P. | 2.3% | 1,859,458 | -4.3% | 0.01% | $40,127,104 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.2% | 1,766,187 | +1.5% | 0% | $38,120,267 |
| BAKER BROS. ADVISORS LP | 2.1% | 1,744,406 | 0% | 0.27% | $37,644,281 |
| LOOMIS SAYLES & CO L P | 1.9% | 1,550,328 | +16% | 0.04% | $33,456,078 |
| PERCEPTIVE ADVISORS LLC | 1.8% | 1,462,400 | +227% | 0.92% | $31,558,592 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5% | 1,220,128 | +10% | 0.04% | $26,330,362 |
| Fisher Asset Management, LLC | 1.5% | 1,201,226 | +136% | 0.01% | $25,922,455 |
| Parkman Healthcare Partners LLC | 1.4% | 1,154,487 | -11% | 2.7% | $24,913,829 |
| WELLINGTON MANAGEMENT GROUP LLP | 1.4% | 1,122,532 | +315% | 0% | $24,224,240 |
| Pictet Asset Management Holding SA | 1.3% | 1,049,385 | -17% | 0.02% | $22,645,728 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 40,309 | $1,254,717 | -$692,840 | 3,111.97% | 4 |
| 2025 Q3 | 93,206,726 | $2,011,267,220 | -$24,960,115 | 2,158% | 167 |
| 2025 Q2 | 94,556,649 | $1,321,909,936 | +$44,977,645 | 1,398% | 169 |
| 2025 Q1 | 91,362,677 | $1,231,598,393 | -$2,447,073 | 1,348% | 174 |
| 2024 Q4 | 91,041,740 | $1,745,285,274 | +$57,671,232 | 1,917% | 177 |
| 2024 Q3 | 86,940,196 | $1,978,662,594 | +$415,185,793 | 2,275% | 163 |
| 2024 Q2 | 69,645,524 | $906,163,827 | -$23,346,202 | 1,301% | 137 |
| 2024 Q1 | 71,003,475 | $1,243,165,734 | +$176,083,012 | 1,751% | 134 |
| 2023 Q4 | 60,143,341 | $1,309,923,497 | +$204,167,783 | 2,178% | 131 |
| 2023 Q3 | 50,192,424 | $769,944,861 | +$32,705,128 | 1,534% | 122 |
| 2023 Q2 | 47,119,787 | $1,121,040,780 | +$92,340,222 | 2,379% | 127 |
| 2023 Q1 | 43,068,809 | $1,095,674,908 | +$43,441,205 | 2,544% | 134 |
| 2022 Q4 | 41,109,026 | $1,200,793,517 | +$91,003,851 | 2,921% | 122 |
| 2022 Q3 | 37,976,766 | $778,702,810 | +$213,427,951 | 2,051% | 104 |
| 2022 Q2 | 28,321,810 | $327,687,712 | +$27,237,558 | 1,157.01% | 80 |
| 2022 Q1 | 24,929,839 | $460,937,688 | -$3,304,649 | 1,848.97% | 71 |
| 2021 Q4 | 23,259,955 | $459,848,025 | +$113,447,608 | 1,977% | 52 |
| 2021 Q3 | 13,600,109 | $223,717,000 | +$123,512,129 | 1,644.98% | 38 |
| 2021 Q2 | 6,003,456 | $109,804,000 | +$18,416,912 | 1,829.03% | 24 |
| 2021 Q1 | 5,057,213 | $84,503,000 | +$80,676,000 | 1,671% | 28 |
| 2020 Q4 | 229,000 | $3,767,000 | +$3,767,000 | 1,645.7% | 2 |