| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 8.9% | $134,640,000 | 5,610,000 | Avoro Capital Advisors LLC | 31 Dec 2024 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 5.7% | $106,551,338 | 3,666,598 | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| Kynam Capital Management, LP | 5.37% | $83,444,698 | 3,426,887 | Kynam Capital Management, LP | 30 Jun 2025 | |||
| Flynn James E | 5.25% | $75,299,151 | 3,348,117 | Deerfield Mgmt, L.P. | 06 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 65,065,875 | $1,890,711,857 | +$37,075,375 | $29.06 | 172 |
| 2025 Q2 | 63,893,006 | $1,505,324,602 | +$17,298,219 | $23.56 | 171 |
| 2025 Q1 | 62,915,975 | $1,512,522,250 | -$90,036,678 | $24.02 | 176 |
| 2024 Q4 | 62,912,622 | $2,660,465,176 | +$389,856,746 | $42.29 | 177 |
| 2024 Q3 | 53,519,938 | $2,365,061,400 | -$1,769,076 | $44.20 | 172 |
| 2024 Q2 | 52,988,211 | $1,917,110,562 | +$57,678,654 | $36.18 | 169 |
| 2024 Q1 | 51,298,718 | $2,212,007,022 | +$474,171,827 | $43.12 | 157 |
| 2023 Q4 | 41,345,437 | $635,880,813 | +$44,778,975 | $15.38 | 93 |
| 2023 Q3 | 39,258,779 | $538,195,352 | +$9,620,413 | $13.71 | 84 |
| 2023 Q2 | 38,127,621 | $611,912,465 | +$42,587,635 | $16.05 | 76 |
| 2023 Q1 | 37,354,429 | $289,749,836 | +$137,641,985 | $7.76 | 69 |
| 2022 Q4 | 21,331,464 | $412,748,829 | -$7,253,468 | $19.35 | 57 |
| 2022 Q3 | 21,539,667 | $459,015,997 | +$19,117,341 | $21.31 | 55 |
| 2022 Q2 | 20,391,008 | $277,615,038 | +$7,846,841 | $13.61 | 49 |
| 2022 Q1 | 19,483,745 | $457,319,068 | +$130,146,246 | $23.49 | 49 |
| 2021 Q4 | 14,054,730 | $374,899,000 | +$10,499,638 | $26.72 | 37 |
| 2021 Q3 | 14,710,587 | $252,433,000 | +$4,174,540 | $17.35 | 30 |
| 2021 Q2 | 14,513,290 | $186,104,000 | +$186,104,000 | $13.25 | 21 |