| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +120% | $678,796,830 | +$389,571,468 | 7,833,777 | +135% | FMR LLC | 31 Jul 2025 |
| JANUS HENDERSON GROUP PLC | 11.4% | +8.18% | $409,408,516 | +$50,587,108 | 6,056,339 | +14.1% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6.9% | +34% | $299,939,842 | +$91,911,561 | 3,461,510 | +44.2% | T. Rowe Price Associates, Inc. | 30 Jun 2025 |
| VANGUARD GROUP INC | 5.28% | $189,763,272 | 2,807,149 | The Vanguard Group | 30 Sep 2025 | |||
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.44% | $204,422,873 | 2,775,976 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.5% | +16% | $231,754,330 | +$63,374,124 | 2,766,225 | +37.6% | BlackRock, Inc. | 30 Jun 2025 |
| Vivo Opportunity Fund Holdings, L.P. | 4.2% | -45.7% | $152,178,416 | -$115,402,258 | 2,251,160 | -43.1% | Vivo Opportunity Fund Holdings, L.P. | 30 Sep 2025 |
| Avoro Capital Advisors LLC | 4.1% | $177,632,500 | 2,050,000 | Avoro Capital Advisors LLC | 30 Jun 2025 | |||
| Adage Capital Management, L.P. | 2.64% | -63.7% | $94,746,538 | -$146,988,629 | 1,401,576 | -60.8% | Adage Capital Management, L.P. | 30 Sep 2025 |
| Nantahala Capital Management, LLC | 1.99% | -60.2% | $86,766,978 | -$140,918,982 | 1,001,350 | -61.9% | Nantahala Capital Management, LLC | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 65,164,449 | $4,403,297,813 | +$507,165,695 | $67.60 | 234 |
| 2025 Q2 | 56,749,470 | $4,754,316,405 | +$213,454,357 | $83.78 | 231 |
| 2025 Q1 | 54,568,286 | $3,901,554,193 | +$304,734,926 | $71.45 | 215 |
| 2024 Q4 | 51,039,620 | $2,293,782,533 | +$169,954,638 | $44.95 | 164 |
| 2024 Q3 | 47,119,847 | $2,378,750,710 | +$200,292,187 | $50.49 | 140 |
| 2024 Q2 | 43,315,547 | $1,767,618,917 | +$339,170,617 | $40.80 | 112 |
| 2024 Q1 | 34,986,278 | $1,496,099,214 | +$153,335,358 | $42.80 | 97 |
| 2023 Q4 | 31,409,972 | $1,264,282,488 | +$428,860,586 | $40.25 | 76 |
| 2023 Q3 | 20,301,195 | $598,794,549 | +$451,363,927 | $29.51 | 54 |
| 2023 Q2 | 4,852,710 | $20,757,863 | +$7,837,293 | $4.29 | 22 |
| 2023 Q1 | 3,071,637 | $6,538,076 | +$3,161,387 | $2.14 | 20 |
| 2022 Q4 | 2,785,956 | $5,517,109 | +$81,616 | $1.98 | 22 |
| 2022 Q3 | 2,781,988 | $4,645,586 | +$4,630,000 | $1.67 | 14 |