| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Prosight Management, LP | 9.9% | $15,638,344 | 6,543,240 | Prosight Management, LP | 30 Sep 2025 | |||
| Redmile Group, LLC | 9.9% | -16% | $5,422,231 | +$617,470 | 6,379,095 | +13% | Redmile Group, LLC | 25 Aug 2025 |
| ORBIMED ADVISORS LLC | 10% | $5,107,963 | 6,306,127 | ORBIMED ADVISORS LLC | 25 Aug 2025 | |||
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9.8% | $3,740,000 | 4,675,000 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| VANGUARD GROUP INC | 4.5% | $1,437,343 | 2,148,174 | The Vanguard Group | 30 Jun 2025 | |||
| BlackRock, Inc. | 1.8% | $69,509 | 878,754 | BlackRock, Inc. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 9.5% | 6,306,127 | 0.36% | $15,071,644 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9.5% | 6,306,127 | +35% | 0.02% | $15,071,644 |
| Redmile Group, LLC | 8.4% | 5,539,724 | 0% | 1.3% | $13,239,940 |
| Prosight Management, LP | 8.2% | 5,451,195 | -18% | 3.1% | $13,028,356 |
| VANGUARD GROUP INC | 3.2% | 2,128,401 | -0.92% | 0% | $5,086,878 |
| 683 Capital Management, LLC | 2.3% | 1,532,216 | +40% | 0.33% | $3,661,996 |
| CLARK ESTATES INC/NY | 2.2% | 1,475,648 | 0% | 0.81% | $3,526,799 |
| PINNACLE ASSOCIATES LTD | 2.1% | 1,388,723 | +1.8% | 0.04% | $3,319,048 |
| BANK OF AMERICA CORP /DE/ | 1.7% | 1,131,888 | +2968% | 0% | $2,705,212 |
| MILLENNIUM MANAGEMENT LLC | 1% | 690,901 | -18% | 0% | $1,651,253 |
| MARSHALL WACE, LLP | 0.99% | 656,653 | 0% | $1,569,399 | |
| TAKEDA PHARMACEUTICAL CO LTD | 0.78% | 515,619 | 0% | 7.5% | $1,232,329 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.71% | 467,959 | 0% | 0% | $1,118,971 |
| BlackRock, Inc. | 0.62% | 411,292 | -53% | 0% | $982,988 |
| TWO SIGMA INVESTMENTS, LP | 0.62% | 408,598 | +431% | 0% | $976,549 |
| ACADIAN ASSET MANAGEMENT LLC | 0.5% | 329,288 | +26% | 0% | $785,000 |
| RENAISSANCE TECHNOLOGIES LLC | 0.33% | 216,867 | +469% | 0% | $518,312 |
| STATE STREET CORP | 0.27% | 176,718 | 0% | 0% | $422,356 |
| Pathstone Holdings, LLC | 0.24% | 157,083 | -50% | 0% | $375,429 |
| TWO SIGMA ADVISERS, LP | 0.17% | 112,677 | +705% | 0% | $269,298 |
| Bank of New York Mellon Corp | 0.17% | 110,394 | 0% | 0% | $263,842 |
| JANE STREET GROUP, LLC | 0.15% | 99,047 | -66% | 0% | $236,722 |
| Aberdeen Group plc | 0.14% | 94,504 | 0% | $225,865 | |
| NORTHERN TRUST CORP | 0.14% | 91,272 | -18% | 0% | $218,140 |
| LBJ Family Wealth Advisors, Ltd. | 0.12% | 82,177 | 0.11% | $196,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 104,809 | $382,606 | +$82,606 | $3.65 | 2 |
| 2025 Q3 | 36,387,666 | $86,952,184 | +$19,207,893 | $2.39 | 55 |
| 2025 Q2 | 28,683,537 | $22,652,305 | -$2,108,587 | $0.7918 | 60 |
| 2025 Q1 | 31,187,405 | $29,629,278 | -$448,919 | $0.9501 | 75 |
| 2024 Q4 | 31,630,688 | $38,272,386 | -$6,568,042 | $1.21 | 73 |
| 2024 Q3 | 34,264,458 | $119,683,589 | +$7,366,433 | $3.49 | 75 |
| 2024 Q2 | 34,177,881 | $131,925,768 | +$4,021,586 | $3.86 | 74 |
| 2024 Q1 | 31,464,617 | $281,294,360 | +$23,128,263 | $8.94 | 68 |
| 2023 Q4 | 29,145,072 | $207,807,364 | +$49,347,094 | $7.13 | 57 |
| 2023 Q3 | 19,886,098 | $30,226,948 | -$551,306 | $1.52 | 39 |
| 2023 Q2 | 20,147,579 | $62,861,356 | +$1,104,302 | $3.12 | 41 |
| 2023 Q1 | 20,310,220 | $59,712,941 | -$164,772 | $2.94 | 48 |
| 2022 Q4 | 20,382,396 | $46,879,443 | -$783,480 | $2.30 | 46 |
| 2022 Q3 | 20,630,140 | $55,696,000 | -$2,846,910 | $2.70 | 62 |
| 2022 Q2 | 21,419,836 | $86,960,000 | -$10,408,230 | $4.06 | 65 |
| 2022 Q1 | 23,972,896 | $102,126,074 | -$3,479,215 | $4.26 | 74 |
| 2021 Q4 | 24,042,241 | $204,591,464 | -$62,878,426 | $8.51 | 80 |
| 2021 Q3 | 25,772,686 | $525,252,762 | -$13,482,057 | $20.38 | 69 |
| 2021 Q2 | 25,886,732 | $750,457,238 | +$70,651,136 | $28.99 | 66 |
| 2021 Q1 | 23,449,036 | $682,731,224 | -$1,668,878 | $29.24 | 55 |
| 2020 Q4 | 22,309,276 | $1,151,016,672 | +$1,151,016,672 | $52.41 | 58 |