| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $462,516,730 | 14,114,029 | FMR LLC | 31 Dec 2024 | |||
| Invus Global Management, LLC | 11.4% | $354,735,676 | 10,825,013 | Invus Public Equities, L.P. | 31 Dec 2024 | |||
| Redmile Group, LLC | 9.9% | $323,935,513 | 9,885,124 | Redmile Group, LLC | 31 Dec 2024 | |||
| Samsara BioCapital, L.P. | 7.2% | $260,368,230 | 6,991,553 | Srinivas Akkaraju | 03 Oct 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 7.2% | -22.2% | $256,337,816 | -$69,951,020 | 6,883,400 | -21.4% | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 116,001,007 | $4,320,221,220 | +$233,668,960 | $37.24 | 236 |
| 2025 Q2 | 109,769,887 | $3,888,022,565 | +$178,857,616 | $35.42 | 232 |
| 2025 Q1 | 104,837,027 | $3,371,744,330 | -$33,218,326 | $32.15 | 229 |
| 2024 Q4 | 104,353,902 | $4,510,154,731 | +$721,146,778 | $43.22 | 222 |
| 2024 Q3 | 88,604,135 | $710,205,939 | -$73,277,440 | $8.01 | 160 |
| 2024 Q2 | 85,434,499 | $711,664,111 | -$4,950,113 | $8.33 | 162 |
| 2024 Q1 | 84,734,135 | $1,504,788,501 | +$67,726,708 | $17.76 | 157 |
| 2023 Q4 | 80,943,926 | $1,521,656,403 | +$517,112,415 | $18.8 | 132 |
| 2023 Q3 | 53,895,100 | $382,656,903 | +$18,522,945 | $7.1 | 88 |
| 2023 Q2 | 51,228,704 | $386,281,569 | +$33,000,083 | $7.54 | 84 |
| 2023 Q1 | 46,757,512 | $374,054,599 | +$11,082,114 | $8 | 87 |
| 2022 Q4 | 45,333,011 | $410,152,108 | +$2,732,733 | $9.05 | 81 |
| 2022 Q3 | 45,164,687 | $313,040,444 | -$16,563,841 | $6.93 | 82 |
| 2022 Q2 | 45,281,459 | $248,583,110 | +$52,865,616 | $5.49 | 79 |
| 2022 Q1 | 31,209,855 | $402,214,995 | +$10,815,747 | $12.89 | 93 |
| 2021 Q4 | 29,740,871 | $738,819,034 | +$15,510,887 | $24.84 | 88 |
| 2021 Q3 | 28,810,380 | $951,262,749 | +$11,867,101 | $33.02 | 99 |
| 2021 Q2 | 28,510,093 | $824,160,826 | -$12,044,776 | $28.9 | 103 |
| 2021 Q1 | 27,794,872 | $1,407,976,193 | +$51,779,290 | $50.66 | 120 |
| 2020 Q4 | 26,801,660 | $1,300,641,545 | +$270,628,080 | $48.53 | 109 |
| 2020 Q3 | 21,238,449 | $375,759,713 | +$18,169,859 | $17.69 | 69 |
| 2020 Q2 | 20,200,219 | $367,837,744 | +$19,852,838 | $18.21 | 67 |
| 2020 Q1 | 19,252,354 | $233,155,834 | +$4,929,230 | $12.11 | 62 |
| 2019 Q4 | 18,828,791 | $248,161,414 | +$10,851,069 | $13.18 | 57 |
| 2019 Q3 | 18,085,569 | $161,872,847 | -$1,742,582 | $8.95 | 55 |
| 2019 Q2 | 17,774,340 | $281,769,575 | +$80,912,370 | $15.86 | 63 |
| 2019 Q1 | 14,088,534 | $264,715,687 | +$12,134,175 | $18.79 | 43 |
| 2018 Q4 | 13,390,978 | $307,589,000 | +$6,478,659 | $22.97 | 40 |
| 2018 Q3 | 13,104,137 | $333,760,000 | +$19,064,124 | $25.75 | 37 |
| 2018 Q2 | 12,530,479 | $191,049,000 | +$191,049,000 | $15.6 | 28 |