Security Snapshot

Q32 Bio Inc. - COMMON STOCK (QTTB) Institutional Ownership

CUSIP: 746964105

13F Institutional Holders and Ownership History from Q1 2024 to Q1 2026

Latest Period

Q4 2025

Institutions Reporting

51

Shares (Excl. Options)

8,043,846

Price

$3.32

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Type / Class
Equity / COMMON STOCK
Symbol
QTTB on Nasdaq
Shares outstanding
16,939,752
Price per share
$5.90
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
8,043,846
Total reported value
$26,659,216
% of total 13F portfolios
0%
Share change
-384,630
Value change
-$1,063,038
Number of holders
51
Price from insider filings
$5.90
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Quick Takeaways

  • QTTB - Q32 Bio Inc. - COMMON STOCK is tracked under CUSIP 746964105.
  • 51 institutions reported positions in Q4 2025.
  • 5 significant owners is listed from Schedule 13D/13G reporting.

What Changed

  • Holder count moved from 51 to 12 between Q4 2025 and Q1 2026.
  • Reported value moved from $26,659,216 to $11,179,074.

Why This Matters

  • You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
  • 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.

Source Evidence

Source: SEC Form 13F

Latest holder context comes from 51 institutions filings for Q4 2025.

Open SEC Evidence

Investment Quick Answers

What is CUSIP 746964105?
CUSIP 746964105 identifies QTTB - Q32 Bio Inc. - COMMON STOCK in SEC 13F datasets.

Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.

Significant Owners of Q32 Bio Inc. - COMMON STOCK (QTTB) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
ORBIMED ADVISORS LLC 13% -14% $13,292,623 2,252,987 0% ORBIMED ADVISORS LLC 05 May 2026
Point72 Asset Management, L.P. 9.9% $8,085,220 2,057,308 Point72 Asset Management, L.P. 17 Feb 2026
Opaleye Management Inc. 8.6% -0.67% $7,411,745 1,256,228 0% Opaleye Management Inc. 31 Mar 2026
PFIZER INC 2.3% $994,442 277,777 Pfizer Inc. (IRS Identification No.: 13-5315170) 31 Dec 2024
BRISTOL MYERS SQUIBB CO 1.6% $312,381 200,244 BRISTOL MYERS SQUIBB CO 31 Dec 2024

As of 31 Dec 2025, 51 institutional investors reported holding 8,043,846 shares of Q32 Bio Inc. - COMMON STOCK (QTTB). This represents 47% of the company’s total 16,939,752 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Q32 Bio Inc. - COMMON STOCK (QTTB) together control 47% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ORBIMED ADVISORS LLC 13% 2,252,987 0% 0.16% $7,479,917
Atlas Venture Life Science Advisors, LLC 12% 2,092,106 0% 0.8% $6,945,792
Carlyle Group Inc. 6.5% 1,102,741 0% 0.03% $3,616,990
ACORN CAPITAL ADVISORS, LLC 2.9% 493,425 -39% 0.56% $1,638,171
VANGUARD GROUP INC 1.9% 321,051 +8.7% 0% $1,065,889
ARCH Venture Management, LLC 1.9% 320,482 0% 0.16% $1,064,000
Pfizer Inc 1.6% 277,777 0% 0.39% $922,220
Sanofi 1.4% 244,083 0% 0.26% $810,356
Opaleye Management Inc. 1.3% 213,363 0.09% $708,365
GEODE CAPITAL MANAGEMENT, LLC 0.63% 106,113 +20% 0% $352,395
RENAISSANCE TECHNOLOGIES LLC 0.59% 99,600 +111% 0% $330,672
BlackRock, Inc. 0.35% 59,932 -36% 0% $198,974
MILLENNIUM MANAGEMENT LLC 0.3% 51,268 -51% 0% $170,210
Monaco Asset Management SAM 0.3% 50,919 -84% 0.05% $169,051
ACADIAN ASSET MANAGEMENT LLC 0.29% 48,373 +63% 0% $159,000
TWO SIGMA INVESTMENTS, LP 0.28% 46,825 +49% 0% $155,459
CITADEL ADVISORS LLC 0.27% 45,728 +352% 0% $151,817
Affinity Asset Advisors, LLC 0.16% 27,777 0% 0.01% $92,220
JANE STREET GROUP, LLC 0.15% 25,374 0% $84,242
NORTHERN TRUST CORP 0.15% 25,033 -22% 0% $83,110
HRT FINANCIAL LP 0.15% 24,698 +66% 0% $81,000
STATE STREET CORP 0.13% 21,237 0% 0% $70,507
XTX Topco Ltd 0.12% 20,353 0% $67,572
ADAR1 Capital Management, LLC 0.12% 20,000 0% $66,400
Scientech Research LLC 0.09% 15,510 0.03% $51,493

Institutional Holders of Q32 Bio Inc. - COMMON STOCK (QTTB) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2026 Q1 1,741,267 $11,179,074 +$139,583 $6.42 12
2025 Q4 8,043,846 $26,659,216 -$1,063,038 $3.32 51
2025 Q3 8,428,600 $16,632,224 -$986,951 $1.98 52
2025 Q2 8,978,370 $13,355,302 -$657,201 $1.49 59
2025 Q1 9,406,123 $15,511,257 -$5,227,234 $1.65 71
2024 Q4 10,994,953 $37,808,803 -$51,251,129 $3.44 88
2024 Q3 9,108,413 $405,845,227 +$55,628,540 $44.62 71
2024 Q2 8,065,328 $144,178,979 +$11,388,677 $17.95 54
2024 Q1 7,430,290 $125,894,701 +$125,894,701 $17.04 38
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