Security Snapshot

Q32 Bio Inc. - Common Stock, par value $0.0001 per share (QTTB) Institutional Ownership

CUSIP: 746964105

13F Institutional Holders and Ownership History from Q1 2024 to Q1 2026

Latest Period

Q1 2026

Institutions Reporting

53

Shares (Excl. Options)

9,428,888

Price

$6.42

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Latest holder snapshot 5 signals
Portfolio coverage rank
0%
Share change
+1,349,287
Value change
+$9,025,150
Number of holders
53
Issuer context Names, identifiers, and filing context for this profile. 3 identity fields
Shares outstanding
23,698,939
SEC-reported price per share
$10.31
Insider filing price
$10.31
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors

Key facts

  • QTTB - Q32 Bio Inc. - Common Stock, par value $0.0001 per share is tracked under CUSIP 746964105.
  • 53 institutions reported positions in Q1 2026.
  • 9 significant owners is listed from Schedule 13D/13G reporting.

Change

  • Holder count moved from 51 to 53 between Q4 2025 and Q1 2026.
  • SEC-reported value moved from $26,659,216 to $60,617,009.

Research use

  • You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
  • 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.

Evidence

Source: SEC Form 13F

Latest holder context comes from 53 institutions filings for Q1 2026.

Open SEC evidence

Security key

746964105

Latest holder period

Q1 2026

13F holders

53

13D/G owners

9

CIK / CUSIP context first

13D/G owners

Significant owners

Large-stake holder rows connected to Schedule 13D/G evidence.

Rows
9
Security
QTTB
Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
ORBIMED ADVISORS LLC 17% +32% $22,703,928 +$10,312,500 4,127,987 +83% ORBIMED ADVISORS LLC 28 May 2026
BIOTECHNOLOGY VALUE FUND L P 10% $13,021,382 2,367,524 BVF PARTNERS L P/IL 28 May 2026
RA CAPITAL MANAGEMENT, L.P. 9.8% $12,828,514 2,332,457 RA Capital Management, L.P. 28 May 2026
Sirenia Capital Management LP 9.9% $12,138,117 2,057,308 Sirenia Capital Management LP 31 Mar 2026
Opaleye Management Inc. 8.6% -0.67% $7,411,745 1,256,228 0% Opaleye Management Inc. 31 Mar 2026
Point72 Asset Management, L.P. 5.7% -42% $5,656,731 -$6,481,386 958,768 -53% Point72 Asset Management, L.P. 31 Mar 2026
Atlas Venture Fund X, L.P. 3.6% $4,753,436 864,261 Atlas Venture Fund X, L.P. 26 May 2026
PFIZER INC 2.3% $994,442 277,777 Pfizer Inc. (IRS Identification No.: 13-5315170) 31 Dec 2024
BRISTOL MYERS SQUIBB CO 1.6% $312,381 200,244 BRISTOL MYERS SQUIBB CO 31 Dec 2024

As of 31 Mar 2026, 53 institutional investors reported holding 9,428,888 shares of Q32 Bio Inc. - Common Stock, par value $0.0001 per share (QTTB). This represents 40% of the company’s total 23,698,939 outstanding shares.

13F concentration

Top 25 institutional shareholders

Largest 13F positions for this security by reported shares and value.

Top holder share
39%
Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ORBIMED ADVISORS LLC 9.5% 2,252,987 0% 0.33% $14,464,177
Atlas Venture Life Science Advisors, LLC 8.8% 2,092,106 0% 1.7% $13,431,321
Opaleye Management Inc. 5.3% 1,256,228 +489% 1.1% $8,064,984
Carlyle Group Inc. 4.7% 1,102,741 0% 0.07% $7,079,597
ARCH Venture Management, LLC 1.4% 320,482 0% 0.3% $2,057,494
ACORN CAPITAL ADVISORS, LLC 1.3% 315,052 -36% 0.57% $2,022,634
VANGUARD CAPITAL MANAGEMENT LLC 1.3% 306,401 0% 0% $1,967,094
MACKENZIE FINANCIAL CORP 1% 246,304 0% $1,581,272
Sanofi 1% 244,083 0% 0.47% $1,567,013
RENAISSANCE TECHNOLOGIES LLC 0.87% 206,915 +108% 0% $1,328,394
ACADIAN ASSET MANAGEMENT LLC 0.73% 172,586 +257% 0% $1,106,000
MONIMUS CAPITAL MANAGEMENT, LP 0.57% 134,310 0.24% $862,270
GEODE CAPITAL MANAGEMENT, LLC 0.5% 118,152 +11% 0% $758,740
Pfizer Inc 0.43% 101,618 -63% 0.31% $736,731
BlackRock, Inc. 0.36% 86,147 +44% 0% $553,063
JANE STREET GROUP, LLC 0.28% 65,599 +159% 0% $421,145
MARSHALL WACE, LLP 0.22% 52,440 0% $336,664
VANGUARD FIDUCIARY TRUST CO 0.21% 49,995 0% 0% $320,968
TWO SIGMA INVESTMENTS, LP 0.18% 42,346 -9.6% 0% $271,861
STATE STREET CORP 0.18% 41,514 +95% 0% $266,520
Cambridge Investment Research Advisors, Inc. 0.15% 35,025 0% $225,000
ADAR1 Capital Management, LLC 0.15% 35,000 +75% 0.01% $224,700
Affinity Asset Advisors, LLC 0.12% 27,777 0% 0.01% $178,328
NORTHERN TRUST CORP 0.11% 25,033 0% 0% $160,712
Cetera Investment Advisers 0.09% 20,695 0% $132,862

Quarter history

Institutional holders across reporting periods

Holder count, reported shares/value, and median price by quarter.

Periods
9
Latest
Q1 2026
Rows shown
1-9 of 9
Period 13F Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2026 Q1 9,428,888 $60,617,009 +$9,025,150 $6.42 53
2025 Q4 8,043,846 $26,659,216 -$1,063,038 $3.32 51
2025 Q3 8,428,600 $16,632,224 -$986,951 $1.98 52
2025 Q2 8,978,370 $13,355,302 -$657,201 $1.49 59
2025 Q1 9,406,123 $15,511,257 -$5,227,234 $1.65 71
2024 Q4 10,994,953 $37,808,803 -$51,251,129 $3.44 88
2024 Q3 9,108,413 $405,845,227 +$55,628,540 $44.62 71
2024 Q2 8,065,328 $144,178,979 +$11,388,677 $17.95 54
2024 Q1 7,430,290 $125,894,701 +$125,894,701 $17.04 38
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