| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 9.9% | $8,085,220 | 2,057,308 | Point72 Asset Management, L.P. | 17 Feb 2026 | |||
| Opaleye Management Inc. | 8.6% | $4,936,976 | 1,256,228 | Opaleye Management Inc. | 19 Feb 2026 | |||
| PFIZER INC | 2.3% | $994,442 | 277,777 | Pfizer Inc. (IRS Identification No.: 13-5315170) | 31 Dec 2024 | |||
| BRISTOL MYERS SQUIBB CO | 1.6% | $312,381 | 200,244 | BRISTOL MYERS SQUIBB CO | 31 Dec 2024 |
As of 31 Dec 2025, 51 institutional investors reported holding 8,043,846 shares of Q32 Bio Inc. - Common Stock, par value $0.0001 per share (QTTB). This represents 55% of the company’s total 14,522,867 outstanding shares.
The largest institutional shareholders of Q32 Bio Inc. - Common Stock, par value $0.0001 per share (QTTB) together control 55% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 16% | 2,252,987 | 0% | 0.16% | $7,479,917 |
| Atlas Venture Life Science Advisors, LLC | 14% | 2,092,106 | 0% | 0.8% | $6,945,792 |
| Carlyle Group Inc. | 7.6% | 1,102,741 | 0% | 0.03% | $3,616,990 |
| ACORN CAPITAL ADVISORS, LLC | 3.4% | 493,425 | -39% | 0.56% | $1,638,171 |
| VANGUARD GROUP INC | 2.2% | 321,051 | +8.7% | 0% | $1,065,889 |
| ARCH Venture Management, LLC | 2.2% | 320,482 | 0% | 0.16% | $1,064,000 |
| Pfizer Inc | 1.9% | 277,777 | 0% | 0.39% | $922,220 |
| Sanofi | 1.7% | 244,083 | 0% | 0.26% | $810,356 |
| Opaleye Management Inc. | 1.5% | 213,363 | 0.09% | $708,365 | |
| GEODE CAPITAL MANAGEMENT, LLC | 0.73% | 106,113 | +20% | 0% | $352,395 |
| RENAISSANCE TECHNOLOGIES LLC | 0.69% | 99,600 | +111% | 0% | $330,672 |
| BlackRock, Inc. | 0.41% | 59,932 | -36% | 0% | $198,974 |
| MILLENNIUM MANAGEMENT LLC | 0.35% | 51,268 | -51% | 0% | $170,210 |
| Monaco Asset Management SAM | 0.35% | 50,919 | -84% | 0.05% | $169,051 |
| ACADIAN ASSET MANAGEMENT LLC | 0.33% | 48,373 | +63% | 0% | $159,000 |
| TWO SIGMA INVESTMENTS, LP | 0.32% | 46,825 | +49% | 0% | $155,459 |
| CITADEL ADVISORS LLC | 0.31% | 45,728 | +352% | 0% | $151,817 |
| Affinity Asset Advisors, LLC | 0.19% | 27,777 | 0% | 0.01% | $92,220 |
| JANE STREET GROUP, LLC | 0.17% | 25,374 | 0% | $84,242 | |
| NORTHERN TRUST CORP | 0.17% | 25,033 | -22% | 0% | $83,110 |
| HRT FINANCIAL LP | 0.17% | 24,698 | +66% | 0% | $81,000 |
| STATE STREET CORP | 0.15% | 21,237 | 0% | 0% | $70,507 |
| XTX Topco Ltd | 0.14% | 20,353 | 0% | $67,572 | |
| ADAR1 Capital Management, LLC | 0.14% | 20,000 | 0% | $66,400 | |
| Scientech Research LLC | 0.11% | 15,510 | 0.03% | $51,493 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 8,043,846 | $26,659,216 | -$1,063,038 | $3.32 | 51 |
| 2025 Q3 | 8,428,600 | $16,632,224 | -$986,752 | $1.98 | 52 |
| 2025 Q2 | 8,978,370 | $13,355,302 | -$657,201 | $1.49 | 59 |
| 2025 Q1 | 9,406,123 | $15,511,257 | -$5,227,234 | $1.65 | 71 |
| 2024 Q4 | 10,994,953 | $37,808,803 | -$51,251,129 | $3.44 | 88 |
| 2024 Q3 | 9,108,413 | $405,845,227 | +$55,628,540 | $44.62 | 71 |
| 2024 Q2 | 8,065,328 | $144,178,979 | +$11,388,677 | $17.95 | 54 |
| 2024 Q1 | 7,430,290 | $125,894,701 | +$125,894,701 | $17.04 | 38 |