| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 9.4% | $6,965,407 | 4,975,291 | ORBIMED ADVISORS LLC | 23 Oct 2025 | |||
| TANG CAPITAL MANAGEMENT LLC | 8.9% | $6,702,907 | 4,720,357 | TANG CAPITAL MANAGEMENT, LLC | 16 Sep 2025 | |||
| BML Investment Partners, L.P. | 6.7% | $3,744,019 | 3,466,684 | BML Investment Partners, L.P. | 31 Dec 2024 | |||
| Sio Capital Management, LLC | 5% | -32% | $3,691,167 | -$1,538,387 | 2,636,548 | -29% | Sio Capital Management, LLC | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 11% | 5,975,291 | -7.7% | 0.2% | $8,365,407 |
| BML Capital Management, LLC | 10% | 5,292,000 | +5.8% | 6.8% | $7,408,800 |
| TANG CAPITAL MANAGEMENT LLC | 9% | 4,785,201 | 0.26% | $6,699,281 | |
| ArrowMark Colorado Holdings LLC | 6.2% | 3,301,341 | +3.6% | 0.09% | $4,621,877 |
| Sio Capital Management, LLC | 5% | 2,636,548 | -29% | 0.93% | $3,691,167 |
| Euclidean Capital LLC | 5% | 2,627,643 | 0% | 1.5% | $3,678,700 |
| VANGUARD GROUP INC | 4.1% | 2,163,027 | +0.44% | 0% | $3,028,239 |
| ACADIAN ASSET MANAGEMENT LLC | 3.9% | 2,066,137 | 0% | 0.01% | $2,891,000 |
| Stonepine Capital Management, LLC | 2.6% | 1,370,139 | +62% | 1.6% | $1,918,195 |
| BlackRock, Inc. | 2.1% | 1,104,140 | -3.2% | 0% | $1,545,795 |
| MARSHALL WACE, LLP | 1.2% | 612,626 | 0% | $857,677 | |
| Aldebaran Capital, LLC | 0.95% | 504,128 | -2.1% | 0.65% | $705,779 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.82% | 431,820 | -0.2% | 0% | $604,698 |
| TWO SIGMA ADVISERS, LP | 0.79% | 417,900 | -14% | 0% | $585,060 |
| JANE STREET GROUP, LLC | 0.72% | 382,050 | 0% | $534,870 | |
| NORTHERN TRUST CORP | 0.72% | 380,813 | +229% | 0% | $533,138 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.61% | 320,653 | +115% | 0.01% | $448,914 |
| Walleye Capital LLC | 0.53% | 278,459 | +258% | 0% | $389,843 |
| TWO SIGMA INVESTMENTS, LP | 0.51% | 269,621 | -7.5% | 0% | $377,469 |
| RBF Capital, LLC | 0.46% | 245,561 | 0% | 0.02% | $343,785 |
| Peapod Lane Capital LLC | 0.38% | 202,784 | -55% | 0.25% | $283,908 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.38% | 201,498 | 0.01% | $282,097 | |
| CITADEL ADVISORS LLC | 0.36% | 193,153 | -25% | 0% | $270,414 |
| GOLDMAN SACHS GROUP INC | 0.32% | 170,802 | +80% | 0% | $239,123 |
| BANK OF AMERICA CORP /DE/ | 0.31% | 162,496 | +458% | 0% | $227,495 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 140,468 | $175,585 | +$21,720 | $1.25 | 1 |
| 2025 Q3 | 37,492,718 | $52,488,395 | +$4,772,987 | $1.40 | 63 |
| 2025 Q2 | 34,680,709 | $36,758,763 | -$2,911,770 | $1.06 | 52 |
| 2025 Q1 | 37,320,031 | $40,676,123 | -$2,281,115 | $1.09 | 54 |
| 2024 Q4 | 38,959,310 | $58,833,270 | -$767,790 | $1.51 | 70 |
| 2024 Q3 | 39,023,873 | $58,153,846 | -$2,416,795 | $1.49 | 73 |
| 2024 Q2 | 40,492,185 | $65,594,864 | -$3,771,661 | $1.62 | 91 |
| 2024 Q1 | 42,725,320 | $72,627,924 | -$11,853,919 | $1.70 | 96 |
| 2023 Q4 | 46,465,983 | $144,025,863 | -$52,160,467 | $3.10 | 97 |
| 2023 Q3 | 54,236,025 | $333,006,052 | +$15,386,619 | $6.14 | 103 |
| 2023 Q2 | 51,696,984 | $323,689,509 | +$3,281,155 | $6.26 | 104 |
| 2023 Q1 | 51,513,177 | $245,718,220 | -$16,150,590 | $4.77 | 111 |
| 2022 Q4 | 54,555,170 | $474,625,571 | -$38,255,414 | $8.70 | 113 |
| 2022 Q3 | 58,187,852 | $692,436,457 | -$36,596,424 | $11.90 | 116 |
| 2022 Q2 | 61,123,657 | $870,921,498 | +$53,476,878 | $14.25 | 105 |
| 2022 Q1 | 55,249,345 | $1,150,065,944 | +$162,099,243 | $20.82 | 98 |
| 2021 Q4 | 47,470,437 | $1,096,597,184 | +$15,190,740 | $23.10 | 102 |
| 2021 Q3 | 43,990,444 | $1,310,907,931 | +$46,789,977 | $29.80 | 91 |
| 2021 Q2 | 42,241,228 | $1,442,956,792 | +$80,038,413 | $34.16 | 83 |
| 2021 Q1 | 39,915,363 | $1,312,819,295 | +$51,865,975 | $32.89 | 81 |
| 2020 Q4 | 38,212,089 | $2,335,342,669 | +$185,049,476 | $61.51 | 72 |
| 2020 Q3 | 31,212,908 | $1,098,804,001 | +$1,098,804,001 | $35.50 | 51 |