| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 9.4% | $6,965,407 | 4,975,291 | ORBIMED ADVISORS LLC | 23 Oct 2025 | |||
| TANG CAPITAL MANAGEMENT LLC | 8.9% | $6,702,907 | 4,720,357 | TANG CAPITAL MANAGEMENT, LLC | 16 Sep 2025 | |||
| BML Investment Partners, L.P. | 6.7% | $3,744,019 | 3,466,684 | BML Investment Partners, L.P. | 31 Dec 2024 | |||
| Sio Capital Management, LLC | 4.98% | -32% | $3,691,167 | -$1,538,387 | 2,636,548 | -29% | Sio Capital Management, LLC | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 37,492,718 | $52,488,395 | +$4,772,987 | $1.4 | 63 |
| 2025 Q2 | 34,680,709 | $36,758,763 | -$2,911,770 | $1.06 | 52 |
| 2025 Q1 | 37,320,031 | $40,676,123 | -$2,281,115 | $1.09 | 54 |
| 2024 Q4 | 38,959,310 | $58,833,270 | -$767,790 | $1.51 | 70 |
| 2024 Q3 | 39,023,873 | $58,153,846 | -$2,416,795 | $1.49 | 73 |
| 2024 Q2 | 40,492,185 | $65,594,864 | -$3,771,661 | $1.62 | 91 |
| 2024 Q1 | 42,725,320 | $72,627,924 | -$11,853,919 | $1.7 | 96 |
| 2023 Q4 | 46,465,983 | $144,025,863 | -$52,160,467 | $3.1 | 97 |
| 2023 Q3 | 54,236,025 | $333,006,052 | +$15,386,619 | $6.14 | 103 |
| 2023 Q2 | 51,696,984 | $323,689,509 | +$3,281,155 | $6.26 | 104 |
| 2023 Q1 | 51,513,177 | $245,718,220 | -$16,150,590 | $4.77 | 111 |
| 2022 Q4 | 54,555,170 | $474,625,571 | -$38,255,414 | $8.7 | 113 |
| 2022 Q3 | 58,187,852 | $692,436,457 | -$36,596,424 | $11.9 | 116 |
| 2022 Q2 | 61,123,657 | $870,921,498 | +$53,476,878 | $14.25 | 105 |
| 2022 Q1 | 55,249,345 | $1,150,065,944 | +$162,099,243 | $20.82 | 98 |
| 2021 Q4 | 47,470,437 | $1,096,597,184 | +$15,190,740 | $23.1 | 102 |
| 2021 Q3 | 43,990,444 | $1,310,907,931 | +$46,789,977 | $29.8 | 91 |
| 2021 Q2 | 42,241,228 | $1,442,956,792 | +$80,038,413 | $34.16 | 83 |
| 2021 Q1 | 39,915,363 | $1,312,819,295 | +$51,865,975 | $32.89 | 81 |
| 2020 Q4 | 38,212,089 | $2,335,342,669 | +$185,049,476 | $61.51 | 72 |
| 2020 Q3 | 31,212,908 | $1,098,804,001 | +$1,098,804,001 | $35.5 | 51 |