| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +22.5% | $372M | $142M | 31.8M | +62.1% | FMR LLC | 30 Sep 2025 |
| Deep Track Capital, LP | 6.18% | -34.7% | $153M | -$27.6M | 13.1M | -15.3% | Deep Track Capital, LP | 30 Sep 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 7.3% | $151M | 12.9M | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 | |||
| SUMMER ROAD LLC | 5.7% | $132M | 12.1M | SUMMER ROAD LLC | 04 Dec 2025 | |||
| BlackRock, Inc. | 5.8% | $119M | 10.2M | BlackRock, Inc. | 30 Sep 2025 | |||
| Opaleye Management Inc. | 2.76% | $34.3M | 4.34M | Opaleye Management Inc. | 31 Dec 2024 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 188M | $2.2B | +$371M | $11.69 | 213 |
| 2025 Q2 | 156M | $1.45B | +$187M | $9.28 | 182 |
| 2025 Q1 | 137M | $1.01B | +$22.1M | $7.33 | 195 |
| 2024 Q4 | 134M | $1.14B | -$55.5M | $8.54 | 177 |
| 2024 Q3 | 140M | $1.22B | +$26.6M | $8.70 | 167 |
| 2024 Q2 | 137M | $940M | +$86.9M | $6.84 | 148 |
| 2024 Q1 | 123M | $1.12B | +$454M | $9.10 | 145 |
| 2023 Q4 | 73.7M | $329M | +$151M | $4.46 | 118 |
| 2023 Q3 | 40.4M | $127M | -$14.5M | $3.14 | 112 |
| 2023 Q2 | 43.5M | $224M | +$15.4M | $5.16 | 132 |
| 2023 Q1 | 40.3M | $212M | +$6.22M | $5.27 | 124 |
| 2022 Q4 | 39.6M | $111M | -$11.9M | $2.81 | 110 |
| 2022 Q3 | 42.8M | $178M | -$6.25M | $4.15 | 126 |
| 2022 Q2 | 44.3M | $178M | +$2.78M | $4.02 | 121 |
| 2022 Q1 | 43.5M | $215M | +$8.62M | $4.95 | 127 |
| 2021 Q4 | 41.5M | $289M | -$36.3M | $6.97 | 137 |
| 2021 Q3 | 44.5M | $445M | -$45.7M | $10.00 | 137 |
| 2021 Q2 | 48.3M | $685M | +$14M | $14.18 | 146 |
| 2021 Q1 | 47.2M | $774M | -$65.7M | $16.41 | 149 |
| 2020 Q4 | 50.4M | $1.04B | +$207M | $20.70 | 146 |
| 2020 Q3 | 39.8M | $303M | +$7.27M | $7.61 | 101 |
| 2020 Q2 | 38.7M | $322M | +$85.3M | $8.33 | 103 |
| 2020 Q1 | 28.5M | $141M | +$17.9M | $4.95 | 87 |
| 2019 Q4 | 25.2M | $99.5M | +$4.79M | $3.95 | 77 |
| 2019 Q3 | 23.3M | $70.8M | +$1.14M | $3.04 | 73 |
| 2019 Q2 | 22.7M | $99.9M | +$3.09M | $4.40 | 66 |
| 2019 Q1 | 22.3M | $88.6M | +$2.35M | $3.97 | 65 |
| 2018 Q4 | 21.5M | $85.5M | -$3.74M | $3.98 | 66 |
| 2018 Q3 | 21.6M | $149M | -$1.2M | $6.88 | 72 |
| 2018 Q2 | 22M | $149M | +$9.8M | $6.75 | 69 |
| 2018 Q1 | 20.4M | $133M | +$45.6M | $6.51 | 63 |
| 2017 Q4 | 13.5M | $60.1M | -$11.8M | $4.45 | 67 |
| 2017 Q3 | 15.6M | $96.5M | -$1.1M | $6.18 | 71 |
| 2017 Q2 | 15.5M | $143M | -$26.3M | $9.27 | 71 |
| 2017 Q1 | 18.3M | $170M | +$20.3M | $9.28 | 73 |
| 2016 Q4 | 17.4M | $146M | -$10.2M | $8.37 | 76 |
| 2016 Q3 | 18.8M | $129M | -$2.94M | $6.87 | 70 |
| 2016 Q2 | 19.5M | $96.4M | -$30.4M | $4.95 | 74 |
| 2016 Q1 | 20.9M | $201M | -$1.63M | $9.66 | 64 |
| 2015 Q4 | 21.1M | $197M | -$18.1M | $9.37 | 71 |
| 2015 Q3 | 20M | $282M | +$49.7M | $14.06 | 66 |
| 2015 Q2 | 16.1M | $339M | +$93.8M | $21.03 | 71 |
| 2015 Q1 | 10.7M | $449M | +$241M | $41.99 | 56 |
| 2014 Q4 | 5.01M | $118M | +$9.26M | $23.52 | 36 |
| 2014 Q3 | 4.63M | $69.3M | +$69.3M | $14.97 | 33 |