Nuvalent, Inc. - Class A common stock, $0.0001 par value per share (NUVL) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2021 to Q4 2025

Type / Class
Equity / Class A common stock, $0.0001 par value per share
Symbol
NUVL on Nasdaq
Shares outstanding
94,391,904
Price per share
$111.99
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
79,890,267
Total reported value
$8,035,844,981
% of total 13F portfolios
0.01%
Share change
+7,160,610
Value change
+$723,660,871
Number of holders
231
Price from insider filings
$111.99
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Nuvalent, Inc. - Class A common stock, $0.0001 par value per share (NUVL) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Flynn James E 24% -12% $2,238,152,303 -$71,496,004 22,852,280 -3.1% Deerfield Management Company, L.P. 31 Dec 2025
VANGUARD GROUP INC 6.8% $330,650,007 4,499,864 The Vanguard Group 31 Dec 2024
BlackRock, Inc. 5% +10% $254,746,024 +$29,816,929 3,338,764 +13% BlackRock, Inc. 30 Jun 2025

As of 31 Dec 2025, 231 institutional investors reported holding 79,890,267 shares of Nuvalent, Inc. - Class A common stock, $0.0001 par value per share (NUVL). This represents 85% of the company’s total 94,391,904 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Nuvalent, Inc. - Class A common stock, $0.0001 par value per share (NUVL) together control 72% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
DEERFIELD MANAGEMENT COMPANY, L.P. 18% 17,248,450 -4.1% 22% $1,735,021,586
FMR LLC 11% 10,852,884 +8.4% 0.06% $1,091,691,628
Paradigm Biocapital Advisors LP 5.6% 5,269,433 0% 14% $530,052,265
VANGUARD GROUP INC 5.6% 5,244,271 +14% 0.01% $527,521,219
BlackRock, Inc. 5.1% 4,805,261 +18% 0.01% $483,361,203
WELLINGTON MANAGEMENT GROUP LLP 2.6% 2,461,823 +7% 0.04% $247,634,775
JPMORGAN CHASE & CO 2.3% 2,205,251 +32% 0.01% $221,826,288
PRICE T ROWE ASSOCIATES INC /MD/ 2.3% 2,146,938 +19% 0.02% $215,962,000
RA CAPITAL MANAGEMENT, L.P. 2% 1,880,057 +51% 1.9% $189,114,934
STATE STREET CORP 2% 1,864,675 +18% 0.01% $187,567,658
PERCEPTIVE ADVISORS LLC 1.8% 1,665,105 +6.6% 3.1% $167,492,912
Polar Capital Holdings Plc 1.6% 1,536,859 +50% 0.71% $154,592,647
JANUS HENDERSON GROUP PLC 1.6% 1,499,574 -31% 0.07% $150,822,342
T. Rowe Price Investment Management, Inc. 1.4% 1,319,963 +29% 0.08% $132,776,000
GEODE CAPITAL MANAGEMENT, LLC 1.3% 1,238,234 +13% 0.01% $124,575,027
Bellevue Group AG 1.1% 1,037,468 2% $104,358,906
BRAIDWELL LP 0.87% 821,406 -19% 2.6% $82,625,230
ALLIANCEBERNSTEIN L.P. 0.83% 785,445 +1472% 0.02% $79,007,913
Fairmount Funds Management LLC 0.77% 727,563 0% 5.6% $73,185,562
ADAGE CAPITAL PARTNERS GP, L.L.C. 0.68% 643,000 +12% 0.1% $64,679,370
Woodline Partners LP 0.65% 610,459 -43% 0.24% $61,406,071
GOLDMAN SACHS GROUP INC 0.63% 594,459 +34% 0.01% $59,796,631
NORGES BANK 0.61% 574,242 0.01% $57,763,003
AMERIPRISE FINANCIAL INC 0.6% 564,298 +7.1% 0.01% $56,762,904
Commodore Capital LP 0.58% 550,000 -61% 3.7% $55,324,500

Institutional Holders of Nuvalent, Inc. - Class A common stock, $0.0001 par value per share (NUVL) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 79,890,267 $8,035,844,981 +$723,660,871 $100.59 231
2025 Q3 72,414,075 $6,262,358,862 +$70,662,116 $86.48 195
2025 Q2 71,891,483 $5,485,539,377 +$5,743,600 $76.30 208
2025 Q1 71,880,102 $5,100,674,747 +$85,199,077 $70.92 203
2024 Q4 70,585,119 $5,525,384,396 -$102,099,624 $78.28 215
2024 Q3 70,143,288 $7,174,318,349 +$410,481,392 $102.30 193
2024 Q2 65,593,010 $4,976,262,329 +$148,912,586 $75.86 172
2024 Q1 63,633,075 $4,778,652,162 +$1,132,776 $75.09 178
2023 Q4 63,628,211 $4,682,588,810 +$549,670,471 $73.59 153
2023 Q3 55,841,607 $2,567,111,846 +$26,806,674 $45.97 114
2023 Q2 55,257,193 $2,330,330,728 +$51,446,970 $42.17 107
2023 Q1 54,098,142 $1,410,654,306 +$29,900,324 $26.09 86
2022 Q4 52,907,137 $1,575,613,147 +$247,260,774 $29.78 94
2022 Q3 45,241,538 $879,530,433 -$5,788,194 $19.44 60
2022 Q2 45,903,198 $622,476,308 +$8,465,397 $13.56 53
2022 Q1 45,285,817 $628,970,401 +$30,206,107 $13.89 55
2021 Q4 43,000,522 $813,075,968 +$14,441,765 $19.04 49
2021 Q3 41,108,138 $918,954,049 +$918,954,049 $22.55 46