| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Flynn James E | 28% | $1,732,825,787 | 23,582,278 | Deerfield Management Company, L.P. | 31 Dec 2024 | |||
| VANGUARD GROUP INC | 6.8% | $330,650,007 | 4,499,864 | The Vanguard Group | 31 Dec 2024 | |||
| BlackRock, Inc. | 5% | +10% | $254,746,024 | +$29,816,929 | 3,338,764 | +13% | BlackRock, Inc. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 27% | 17,991,024 | 0% | 24% | $1,555,863,756 |
| FMR LLC | 15% | 10,013,237 | +0.45% | 0.05% | $865,944,758 |
| Paradigm Biocapital Advisors LP | 7.9% | 5,269,433 | 0% | 13% | $455,700,566 |
| VANGUARD GROUP INC | 6.9% | 4,605,007 | +1.8% | 0.01% | $398,241,005 |
| BlackRock, Inc. | 6.1% | 4,085,795 | +0.98% | 0.01% | $353,339,552 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.4% | 2,300,865 | +46% | 0.03% | $198,978,805 |
| JANUS HENDERSON GROUP PLC | 3.3% | 2,188,674 | +23% | 0.09% | $189,340,492 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.7% | 1,810,420 | +0.84% | 0.02% | $156,566,000 |
| JPMORGAN CHASE & CO | 2.5% | 1,674,009 | +40% | 0.01% | $144,768,373 |
| STATE STREET CORP | 2.4% | 1,574,747 | +5.7% | 0% | $136,184,121 |
| PERCEPTIVE ADVISORS LLC | 2.3% | 1,562,336 | +14% | 4% | $135,110,817 |
| Commodore Capital LP | 2.1% | 1,400,000 | +1.8% | 5.9% | $121,072,000 |
| RA CAPITAL MANAGEMENT, L.P. | 1.9% | 1,246,456 | 1.3% | $107,793,515 | |
| Vestal Point Capital, LP | 1.6% | 1,100,000 | +2.3% | 4.3% | $95,128,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.6% | 1,093,993 | +9.7% | 0.01% | $94,623,097 |
| Woodline Partners LP | 1.6% | 1,069,520 | +18% | 0.44% | $92,492,090 |
| Polar Capital Holdings Plc | 1.5% | 1,022,225 | +25% | 0.43% | $88,402,018 |
| T. Rowe Price Investment Management, Inc. | 1.5% | 1,021,236 | -6.7% | 0.05% | $88,317,000 |
| BRAIDWELL LP | 1.5% | 1,012,982 | -14% | 2.6% | $87,602,683 |
| Fairmount Funds Management LLC | 1.1% | 727,563 | 0% | 5.7% | $62,919,648 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0.86% | 574,500 | -0.52% | 0.08% | $49,682,760 |
| AMERIPRISE FINANCIAL INC | 0.79% | 527,050 | +8.8% | 0.01% | $45,579,378 |
| GOLDMAN SACHS GROUP INC | 0.67% | 444,436 | -17% | 0.01% | $38,434,825 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.61% | 404,553 | +17% | 0.01% | $34,985,743 |
| First Turn Management, LLC | 0.59% | 394,754 | +23% | 5.1% | $34,138,326 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 20,747 | $2,087,350 | +$161,176 | $100.61 | 5 |
| 2025 Q3 | 72,412,845 | $6,262,252,861 | +$70,662,116 | $86.48 | 194 |
| 2025 Q2 | 71,891,483 | $5,485,539,377 | +$5,743,600 | $76.30 | 208 |
| 2025 Q1 | 71,880,102 | $5,100,674,747 | +$85,199,077 | $70.92 | 203 |
| 2024 Q4 | 70,585,119 | $5,525,384,396 | -$102,099,624 | $78.28 | 215 |
| 2024 Q3 | 70,143,288 | $7,174,318,349 | +$410,481,392 | $102.30 | 193 |
| 2024 Q2 | 65,593,010 | $4,976,262,329 | +$148,912,586 | $75.86 | 172 |
| 2024 Q1 | 63,633,075 | $4,778,652,162 | +$1,132,776 | $75.09 | 178 |
| 2023 Q4 | 63,628,211 | $4,682,588,810 | +$549,670,471 | $73.59 | 153 |
| 2023 Q3 | 55,841,607 | $2,567,111,846 | +$26,806,674 | $45.97 | 114 |
| 2023 Q2 | 55,257,193 | $2,330,330,728 | +$51,446,970 | $42.17 | 107 |
| 2023 Q1 | 54,098,142 | $1,410,654,306 | +$29,900,324 | $26.09 | 86 |
| 2022 Q4 | 52,907,137 | $1,575,613,147 | +$247,260,774 | $29.78 | 94 |
| 2022 Q3 | 45,241,538 | $879,530,433 | -$5,788,194 | $19.44 | 60 |
| 2022 Q2 | 45,903,198 | $622,476,308 | +$8,465,397 | $13.56 | 53 |
| 2022 Q1 | 45,285,817 | $628,970,401 | +$30,206,107 | $13.89 | 55 |
| 2021 Q4 | 43,000,522 | $813,075,968 | +$14,441,765 | $19.04 | 49 |
| 2021 Q3 | 41,108,138 | $918,954,049 | +$918,954,049 | $22.55 | 46 |