| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 9.9% | $14,799,751 | 7,014,100 | TANG CAPITAL MANAGEMENT, LLC | 17 Jan 2025 | |||
| BlackRock, Inc. | 5% | $7,292,880 | 3,524,322 | BlackRock, Inc. | 30 Sep 2025 | |||
| Samsara BioCapital, L.P. | 4.9% | $8,383,322 | 3,507,666 | Samsara BioCapital, L.P. | 20 Nov 2025 | |||
| CITADEL ADVISORS LLC | 4.1% | $6,003,741 | 2,900,358 | Kenneth Griffin | 30 Sep 2025 | |||
| LSP 6 Holding C.V. | 4% | $5,985,097 | 2,836,539 | LSP 6 Management B.V. | 12 Feb 2025 | |||
| COMMODORE CAPITAL LP | 0.5% | $742,399 | 351,848 | COMMODORE CAPITAL LP | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 15% | 10,805,129 | 0% | 0.28% | $22,366,617 |
| TANG CAPITAL MANAGEMENT LLC | 9.9% | 7,055,576 | 0% | 0.56% | $14,605,042 |
| SAMSARA BIOCAPITAL, LLC | 5.3% | 3,768,035 | 0% | 1% | $7,799,832 |
| BlackRock, Inc. | 5.2% | 3,698,537 | -11% | 0% | $7,655,971 |
| NEA Management Company, LLC | 5% | 3,568,781 | 0% | 0.41% | $7,387,377 |
| SR One Capital Management, LP | 4.7% | 3,333,333 | 0% | 1% | $6,899,999 |
| CITADEL ADVISORS LLC | 4.1% | 2,899,758 | -12% | 0% | $6,002,499 |
| VANGUARD GROUP INC | 3.5% | 2,491,717 | -2.4% | 0% | $5,157,855 |
| Alyeska Investment Group, L.P. | 2.9% | 2,084,696 | 0% | 0.01% | $4,315,321 |
| Monaco Asset Management SAM | 2.8% | 1,970,910 | +24% | 1.5% | $4,079,784 |
| WASATCH ADVISORS LP | 2.3% | 1,637,737 | -8.3% | 0.02% | $3,390,116 |
| STATE STREET CORP | 1.6% | 1,148,115 | +0.89% | 0% | $2,376,598 |
| RENAISSANCE TECHNOLOGIES LLC | 1.6% | 1,145,077 | +64% | 0% | $2,370,309 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.5% | 1,068,105 | -12% | 0% | $2,211,496 |
| AWM Investment Company, Inc. | 1.1% | 800,000 | +14% | 0.16% | $1,656,000 |
| MILLENNIUM MANAGEMENT LLC | 1% | 748,494 | 0% | $1,549,383 | |
| Blackstone Inc. | 1% | 747,044 | 0% | 0.01% | $1,546,381 |
| Peapod Lane Capital LLC | 0.94% | 671,266 | +1.1% | 1.2% | $1,389,704 |
| JPMORGAN CHASE & CO | 0.78% | 558,840 | -3.3% | 0% | $1,156,798 |
| TWO SIGMA INVESTMENTS, LP | 0.73% | 520,172 | +91% | 0% | $1,076,756 |
| ACADIAN ASSET MANAGEMENT LLC | 0.71% | 510,696 | +7.3% | 0% | $1,054,000 |
| MORGAN STANLEY | 0.66% | 473,217 | +46% | 0% | $979,559 |
| BANK OF AMERICA CORP /DE/ | 0.62% | 442,493 | -40% | 0% | $915,960 |
| ROYAL BANK OF CANADA | 0.57% | 406,389 | +0.16% | 0% | $842,000 |
| AQR CAPITAL MANAGEMENT LLC | 0.55% | 392,565 | -13% | 0% | $812,609 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 192 | $355 | +$355 | $1.85 | 1 |
| 2025 Q3 | 57,706,282 | $119,448,874 | -$669,799 | $2.07 | 120 |
| 2025 Q2 | 58,386,753 | $96,921,989 | -$5,560,681 | $1.66 | 104 |
| 2025 Q1 | 61,535,730 | $113,228,164 | -$4,989,963 | $1.84 | 111 |
| 2024 Q4 | 62,166,678 | $154,773,095 | -$34,971,809 | $2.49 | 111 |
| 2024 Q3 | 66,758,587 | $301,729,892 | +$1,030,813 | $4.52 | 117 |
| 2024 Q2 | 66,214,207 | $391,326,357 | -$11,926,340 | $5.91 | 111 |
| 2024 Q1 | 63,548,965 | $686,972,041 | +$247,376,028 | $10.81 | 111 |
| 2023 Q4 | 40,891,599 | $269,870,728 | +$38,368,265 | $6.60 | 92 |
| 2023 Q3 | 36,468,247 | $50,691,612 | -$4,878,224 | $1.39 | 84 |
| 2023 Q2 | 39,512,229 | $86,534,974 | -$7,291,494 | $2.19 | 96 |
| 2023 Q1 | 41,402,353 | $146,948,631 | -$7,757,304 | $3.55 | 99 |
| 2022 Q4 | 42,068,714 | $251,980,265 | -$39,994,490 | $5.99 | 122 |
| 2022 Q3 | 42,690,330 | $561,667,539 | -$60,160,576 | $13.16 | 102 |
| 2022 Q2 | 43,566,118 | $536,732,987 | +$227,214,652 | $12.32 | 111 |
| 2022 Q1 | 25,218,509 | $286,993,783 | +$14,238,706 | $11.38 | 79 |
| 2021 Q4 | 23,873,161 | $366,330,933 | -$43,786,680 | $15.35 | 86 |
| 2021 Q3 | 23,407,302 | $651,156,039 | -$20,923,251 | $27.81 | 82 |
| 2021 Q2 | 24,132,993 | $764,733,969 | -$68,059,037 | $31.69 | 87 |
| 2021 Q1 | 26,232,028 | $862,860,086 | -$12,905,060 | $32.90 | 96 |
| 2020 Q4 | 25,294,750 | $1,554,842,373 | +$8,608,640 | $61.47 | 87 |
| 2020 Q3 | 25,259,445 | $759,507,213 | +$755,561,213 | $30.06 | 56 |
| 2020 Q2 | 124,520 | $3,946,000 | $31.69 | 1 | |
| 2020 Q1 | 124,520 | $3,946,000 | $31.69 | 1 | |
| 2019 Q4 | 124,520 | $3,946,000 | $31.69 | 1 | |
| 2019 Q3 | 124,520 | $3,946,000 | $31.69 | 1 | |
| 2019 Q2 | 124,520 | $3,946,000 | $31.69 | 1 | |
| 2019 Q1 | 124,520 | $3,946,000 | $31.69 | 1 |