| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| HBM Healthcare Investments (Cayman) Ltd. | 8.2% | $5,412,970 | 5,523,439 | HBM Healthcare Investments (Cayman) Ltd. | 31 Dec 2023 | |||
| Novo Holdings A/S | 7.3% | $10,560,967 | 4,981,588 | Novo Holdings A/S | 11 Aug 2025 | |||
| Chernett Jorey | 5.3% | $1,286,550 | 3,477,162 | Chernett Jorey | 30 Oct 2025 | |||
| Samsara BioCapital, L.P. | 3.8% | $2,578,946 | 2,631,578 | Samsara BioCapital, L.P. | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| NOVO HOLDINGS A/S | 3.8% | 2,512,453 | -25% | 0.06% | $912,272 |
| Ikarian Capital, LLC | 2.3% | 1,525,893 | 0.13% | $554,051 | |
| MILLENNIUM MANAGEMENT LLC | 2.1% | 1,392,396 | 0% | $505,579 | |
| MARSHALL WACE, LLP | 1.6% | 1,052,631 | -50% | 0% | $378,947 |
| BANK OF AMERICA CORP /DE/ | 1.2% | 799,953 | -50% | 0% | $290,383 |
| MORGAN STANLEY | 1% | 668,402 | +2.3% | 0% | $242,697 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.9% | 591,180 | 0.01% | $214,657 | |
| RENAISSANCE TECHNOLOGIES LLC | 0.83% | 547,315 | +293% | 0% | $198,730 |
| Point72 Asset Management, L.P. | 0.38% | 250,000 | 0% | $90,775 | |
| XTX Topco Ltd | 0.27% | 179,207 | +514% | 0% | $65,070 |
| Quadrature Capital Ltd | 0.13% | 83,382 | 0% | $30,276 | |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.11% | 75,000 | 0% | 0% | $27,233 |
| GOLDMAN SACHS GROUP INC | 0.1% | 66,564 | 0% | $24,169 | |
| Virtu Financial LLC | 0.06% | 39,063 | 0% | $14,000 | |
| GEODE CAPITAL MANAGEMENT, LLC | 0.05% | 33,307 | 0% | 0% | $12,093 |
| NewEdge Advisors, LLC | 0.04% | 25,692 | +6.1% | 0% | $9,329 |
| Hilton Capital Management, LLC | 0.04% | 25,510 | 0% | $9,263 | |
| PKS Advisory Services, LLC | 0.03% | 19,500 | 0% | $7,080 | |
| UBS Group AG | 0.01% | 7,013 | -47% | 0% | $2,546 |
| CITIGROUP INC | 0% | 1,292 | +311% | 0% | $469 |
| SBI Securities Co., Ltd. | 0% | 122 | -7.6% | 0% | $44 |
| TWO SIGMA SECURITIES, LLC | 0% | 0 | -100% | $0 | |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0% | 0 | -100% | $0 | |
| ACADIAN ASSET MANAGEMENT LLC | 0% | 0 | -100% | $0 | |
| RAYMOND JAMES FINANCIAL INC | 0% | 0 | -100% | $0 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 9,895,875 | $3,589,663 | -$13,417,589 | 36.31% | 21 |
| 2025 Q2 | 18,182,707 | $25,273,480 | -$1,285,024 | 139% | 26 |
| 2025 Q1 | 19,066,617 | $20,781,978 | -$660,538 | 109% | 21 |
| 2024 Q4 | 19,692,862 | $18,114,763 | -$4,833,042 | 92% | 26 |
| 2024 Q3 | 23,591,882 | $24,769,965 | -$2,959,503 | 105% | 19 |
| 2024 Q2 | 26,183,049 | $30,634,167 | -$1,443,320 | 117% | 19 |
| 2024 Q1 | 27,341,910 | $47,354,293 | -$3,558,302 | 173% | 17 |
| 2023 Q4 | 29,400,721 | $55,273,224 | +$999,356 | 188% | 18 |
| 2023 Q3 | 29,668,665 | $41,702,613 | +$24,426,263 | 141% | 19 |
| 2023 Q2 | 12,246,779 | $23,953,554 | -$3,111,706 | 195.5% | 15 |
| 2023 Q1 | 13,917,553 | $26,081,803 | -$1,175,062 | 187.5% | 17 |
| 2022 Q4 | 14,281,285 | $32,846,954 | -$2,578,155 | 230% | 17 |
| 2022 Q3 | 15,335,530 | $41,559,000 | -$326,875 | 271.01% | 20 |
| 2022 Q2 | 15,453,557 | $72,167,000 | +$2,681,635 | 466.99% | 18 |
| 2022 Q1 | 14,858,852 | $76,863,500 | -$1,060,884 | 529.99% | 19 |
| 2021 Q4 | 12,982,583 | $82,349,000 | +$82,349,000 | 640.01% | 19 |