- Common Stock, par value $0.01 per share (HRTX)

Q: What does CUSIP 427746102 represent in this 13F holders report?

CUSIP 427746102 is the security identifier for HRTX - HERON THERAPEUTICS, INC. /DE/ - Common Stock, par value $0.01 per share used to aggregate holder disclosures.

Q: How many institutions held HRTX - HERON THERAPEUTICS, INC. /DE/ - Common Stock, par value $0.01 per share in Q4 2021?

192 institutional investors reported HRTX - HERON THERAPEUTICS, INC. /DE/ - Common Stock, par value $0.01 per share for Q4 2021. Use the holders table for investor-level position and value details.

CUSIP: 427746102

Q4 2021 13F Holders as of 31 Dec 2021

Security type / class: Equity / Common Stock, par value $0.01 per share
Total 13F shares: 117,646,567
Total 13F value: $1,073,655,355
Share change: +8,957,894
Put/Call ratio: 80%
SEC-reported price per share: $9.13
Number of holders: 192
Value change: +$78,398,633
Number of buys: 87
Number of sells: 79
Shares outstanding: 182,615,507

Security key

427746102

Report period

Q4 2021

Institutions

192

Top holders

HRTX full security history Ownership snapshot Full 13F holder table Newer quarter: Q1 2022 Previous quarter: Q3 2021 HERON THERAPEUTICS, INC. /DE/ SEC filings HERON THERAPEUTICS, INC. /DE/ company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 427746102

Newer quarter: Q1 2022 Previous quarter: Q3 2021

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Ownership snapshot

Top reported holders of HRTX - HERON THERAPEUTICS, INC. /DE/ - Common Stock, par value $0.01 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

FRANKLIN RESOURCES INC

Disclosed value leader

FRANKLIN RESOURCES INC

Comparable rows

15/15

Latest evidence

30 Sep 2021

13F Lead comparable stake: 6.6% Showing 1-6 of 15 holder rows.

Quick read

FRANKLIN RESOURCES INC leads the comparable SEC ownership view at 6.6%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens FRANKLIN RESOURCES INC's linked filing trail.

Comparable ownership Top 5

FRANKLIN RESOURCES INC 6.6%

VANGUARD GROUP INC 5.2%

BAKER BROS. ADVISORS LP 4.5%

TANG CAPITAL MANAGEMENT LLC 4.3%

BlackRock Finance, Inc. 4.2%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
FRANKLIN RESOURCES INC	13F Company 13F	6.6%	$128,071,000 11,980,444 shares	—	30 Sep 2021
VANGUARD GROUP INC	13F Company 13F	5.2%	$101,558,000 9,500,292 shares	—	30 Sep 2021
BAKER BROS. ADVISORS LP	13F Company 13F	4.5%	$86,928,000 8,131,678 shares	—	30 Sep 2021
TANG CAPITAL MANAGEMENT LLC	13F Company 13F	4.3%	$84,527,000 7,907,087 shares	—	30 Sep 2021
BlackRock Finance, Inc.	13F Company 13F	4.2%	$82,023,000 7,672,868 shares	—	30 Sep 2021
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC)	13F Company 13F	3.6%	$70,917,000 6,633,916 shares	—	30 Sep 2021

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2021

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

192

117,646,567

Rows available

192

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q4 2021 vs Q3 2021 Across Filers

Q3 2021 holders

189

Q4 2021 holders

192

Holder diff

Investor	Q3 2021 Shares	Q4 2021 Shares	Share Diff	Share Chg %	Q3 2021 value	Q4 2021 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend