| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 15% | 0% | $25,118,211 | +$174,923 | 17,941,579 | +0.7% | Redmile Group, LLC | 02 Jul 2025 |
| VANGUARD GROUP INC | 7.6% | $9,818,776 | 8,766,764 | The Vanguard Group | 30 Jun 2025 | |||
| BlackRock, Inc. | 6.9% | $10,600,447 | 7,852,183 | BlackRock, Inc. | 31 Mar 2025 | |||
| GOLDMAN SACHS GROUP INC | 2% | -77% | $2,546,902 | -$6,958,784 | 2,274,020 | -73% | THE GOLDMAN SACHS GROUP, INC. | 30 Jun 2025 |
| Schonfeld Strategic Advisors LLC | 0.82% | -85% | $1,050,024 | -$7,679,831 | 937,521 | -88% | Schonfeld Strategic Advisors LLC | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Redmile Group, LLC | 11% | 12,872,946 | 0% | 1.6% | $16,219,912 |
| BlackRock, Inc. | 9.3% | 10,680,727 | -1.2% | 0% | $13,457,714 |
| VANGUARD GROUP INC | 7.7% | 8,798,491 | +0.36% | 0% | $11,086,098 |
| Wilshire Advisors LLC | 7.4% | 8,486,822 | 28% | $10,693,396 | |
| JOHNSON & JOHNSON | 3% | 3,379,064 | 0% | 0.85% | $4,257,621 |
| ACADIAN ASSET MANAGEMENT LLC | 2.4% | 2,710,234 | +10% | 0.01% | $3,412,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.2% | 2,530,212 | +4.2% | 0% | $3,188,561 |
| Vestal Point Capital, LP | 2.2% | 2,515,000 | 0% | 0.14% | $3,168,900 |
| STATE STREET CORP | 2.1% | 2,417,135 | +8.4% | 0% | $3,045,590 |
| DIMENSIONAL FUND ADVISORS LP | 1.8% | 2,094,975 | -14% | 0% | $2,637,886 |
| TANG CAPITAL MANAGEMENT LLC | 1.6% | 1,867,773 | 0% | 0.09% | $2,353,394 |
| GOLDMAN SACHS GROUP INC | 1.3% | 1,486,407 | -41% | 0% | $1,872,873 |
| RENAISSANCE TECHNOLOGIES LLC | 1.1% | 1,262,515 | +489% | 0% | $1,590,769 |
| AQR CAPITAL MANAGEMENT LLC | 0.99% | 1,131,414 | +34% | 0% | $1,425,581 |
| TWO SIGMA ADVISERS, LP | 0.88% | 1,007,400 | +104% | 0% | $1,269,324 |
| MILLENNIUM MANAGEMENT LLC | 0.84% | 963,871 | +9.6% | 0% | $1,214,477 |
| MORGAN STANLEY | 0.81% | 929,944 | -62% | 0% | $1,171,730 |
| TWO SIGMA INVESTMENTS, LP | 0.79% | 900,757 | +294% | 0% | $1,134,954 |
| CITADEL ADVISORS LLC | 0.72% | 824,545 | -82% | 0% | $1,038,927 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0.71% | 814,639 | -33% | 0% | $1,026,445 |
| NORTHERN TRUST CORP | 0.71% | 814,465 | -3.5% | 0% | $1,026,226 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.69% | 785,921 | +7.1% | 0% | $990,260 |
| Monaco Asset Management SAM | 0.67% | 770,000 | +14% | 0.36% | $970,200 |
| Bruce & Co., Inc. | 0.64% | 729,188 | +70% | 0.28% | $918,777 |
| Woodline Partners LP | 0.62% | 712,650 | 0% | 0% | $897,939 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 223,278 | $220,114 | +$22,415 | $0.98 | 6 |
| 2025 Q3 | 80,482,515 | $101,400,876 | +$1,893,628 | $1.26 | 137 |
| 2025 Q2 | 79,555,724 | $88,833,451 | -$17,593,195 | $1.12 | 136 |
| 2025 Q1 | 96,451,503 | $76,210,377 | -$16,246,755 | $0.79 | 127 |
| 2024 Q4 | 100,742,490 | $166,216,764 | -$49,322,737 | $1.65 | 154 |
| 2024 Q3 | 114,626,757 | $401,134,107 | -$26,268,311 | $3.50 | 157 |
| 2024 Q2 | 122,159,363 | $400,671,566 | -$37,762,295 | $3.28 | 176 |
| 2024 Q1 | 122,980,750 | $902,678,660 | +$225,457,297 | $7.34 | 160 |
| 2023 Q4 | 95,368,059 | $356,677,597 | -$5,241,221 | $3.74 | 152 |
| 2023 Q3 | 95,698,313 | $202,876,531 | -$41,469,527 | $2.12 | 164 |
| 2023 Q2 | 109,140,532 | $519,540,682 | -$18,388,551 | $4.76 | 183 |
| 2023 Q1 | 112,556,300 | $641,545,712 | -$48,046,056 | $5.70 | 177 |
| 2022 Q4 | 105,538,752 | $1,064,884,147 | -$72,227,908 | $10.09 | 222 |
| 2022 Q3 | 107,847,419 | $2,414,270,747 | -$51,535,763 | $22.41 | 226 |
| 2022 Q2 | 109,105,314 | $2,682,160,938 | +$198,082,382 | $24.78 | 212 |
| 2022 Q1 | 101,146,307 | $3,918,572,903 | +$154,288,770 | $38.77 | 235 |
| 2021 Q4 | 96,474,919 | $5,644,897,783 | +$10,118,846 | $58.51 | 240 |
| 2021 Q3 | 95,702,027 | $5,670,584,893 | +$32,917,992 | $59.27 | 254 |
| 2021 Q2 | 94,438,853 | $8,194,463,579 | +$63,508,082 | $86.79 | 264 |
| 2021 Q1 | 93,763,343 | $7,731,987,612 | +$546,947,235 | $82.45 | 251 |
| 2020 Q4 | 87,411,381 | $7,948,482,716 | -$84,784,180 | $90.93 | 247 |
| 2020 Q3 | 87,813,890 | $3,509,314,003 | +$84,938,020 | $39.97 | 210 |
| 2020 Q2 | 85,944,579 | $2,946,905,994 | +$357,311,792 | $34.31 | 199 |
| 2020 Q1 | 75,606,763 | $1,679,422,294 | +$78,833,879 | $22.21 | 153 |
| 2019 Q4 | 72,206,146 | $1,413,058,139 | -$18,741,577 | $19.57 | 145 |
| 2019 Q3 | 73,759,772 | $1,145,458,451 | +$162,122,671 | $15.53 | 147 |
| 2019 Q2 | 63,158,854 | $1,282,170,068 | +$56,656,459 | $20.30 | 133 |
| 2019 Q1 | 60,804,461 | $1,068,331,832 | +$24,885,328 | $17.57 | 121 |
| 2018 Q4 | 59,421,648 | $762,327,973 | +$32,572,198 | $12.83 | 120 |
| 2018 Q3 | 54,832,749 | $893,221,923 | +$193,920,385 | $16.29 | 116 |
| 2018 Q2 | 43,038,652 | $488,060,307 | +$35,286,017 | $11.34 | 102 |
| 2018 Q1 | 39,404,544 | $384,590,041 | +$45,054,814 | $9.76 | 87 |
| 2017 Q4 | 35,346,074 | $215,961,575 | +$67,123,779 | $6.11 | 78 |
| 2017 Q3 | 25,410,496 | $100,632,735 | -$4,500,070 | $3.96 | 71 |
| 2017 Q2 | 26,610,964 | $86,219,950 | +$4,849,002 | $3.24 | 57 |
| 2017 Q1 | 25,029,354 | $113,880,000 | +$9,086,443 | $4.55 | 51 |
| 2016 Q4 | 23,128,984 | $57,885,000 | +$7,405,875 | $2.51 | 33 |
| 2016 Q3 | 19,481,982 | $60,781,000 | +$17,053,469 | $3.12 | 36 |
| 2016 Q2 | 14,071,764 | $23,921,000 | -$3,087,760 | $1.70 | 37 |
| 2016 Q1 | 15,773,542 | $28,394,000 | -$9,461,086 | $1.80 | 42 |
| 2015 Q4 | 18,614,016 | $62,724,000 | -$726,308 | $3.37 | 51 |
| 2015 Q3 | 18,349,000 | $97,801,000 | +$1,748,454 | $5.33 | 41 |
| 2015 Q2 | 18,018,637 | $116,577,000 | +$48,004,684 | $6.47 | 37 |
| 2015 Q1 | 10,608,782 | $51,875,000 | +$1,628,433 | $4.89 | 25 |
| 2014 Q4 | 10,275,305 | $51,680,000 | -$3,435 | $5.02 | 23 |
| 2014 Q3 | 10,270,522 | $52,580,000 | +$2,082,379 | $5.10 | 22 |
| 2014 Q2 | 9,853,337 | $62,410,000 | +$1,716,802 | $6.31 | 21 |
| 2014 Q1 | 9,563,610 | $92,835,964 | +$30,694,357 | $9.74 | 21 |