| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 13.4% | $140,468,212 | 7,918,163 | ORBIMED ADVISORS LLC | 16 Jun 2025 | |||
| FMR LLC | 13.3% | $161,103,383 | 7,870,219 | FMR LLC | 30 Sep 2025 | |||
| Commodore Capital LP | 9.9% | $135,215,385 | 6,022,957 | Commodore Capital LP | 30 Jun 2025 | |||
| Fairmount Funds Management LLC | 6.3% | -4.3% | $83,321,918 | +$11,419,103 | 3,711,444 | +16% | Fairmount Funds Management LLC | 30 Jun 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 5.4% | $66,042,996 | 3,226,331 | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 | |||
| BlackRock, Inc. | 5.1% | $59,005,266 | 2,941,395 | BlackRock, Inc. | 30 Jun 2025 | |||
| Polar Capital Holdings Plc | 5.17% | +5.6% | $56,952,978 | +$3,304,932 | 2,536,881 | +6.2% | Polar Capital Holdings Plc | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 59,389,507 | $1,215,687,864 | -$296,038 | $20.47 | 132 |
| 2025 Q2 | 59,434,902 | $1,192,251,085 | +$192,194,924 | $20.06 | 123 |
| 2025 Q1 | 49,886,849 | $983,923,667 | +$4,352,699 | $19.68 | 118 |
| 2024 Q4 | 49,624,914 | $1,116,597,658 | +$24,828,957 | $22.5 | 111 |
| 2024 Q3 | 47,688,348 | $1,218,010,157 | -$20,810,259 | $25.54 | 100 |
| 2024 Q2 | 48,318,843 | $1,129,194,355 | +$91,652,714 | $23.37 | 91 |
| 2024 Q1 | 44,456,336 | $780,753,492 | +$95,045,035 | $17.59 | 72 |
| 2023 Q4 | 39,000,634 | $539,791,932 | -$652,659 | $13.84 | 61 |
| 2023 Q3 | 39,076,502 | $533,779,750 | -$2,178,662 | $13.66 | 60 |
| 2023 Q2 | 39,092,843 | $797,915,923 | +$112,876,379 | $20.41 | 61 |
| 2023 Q1 | 33,557,749 | $734,910,999 | +$734,911,000 | $21.9 | 44 |