| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 12.2% | -11.4% | $35,423,231 | 9,785,423 | 0% | ORBIMED ADVISORS LLC | 12 May 2025 | |
| MILLER RICHARD A MD | 7.7% | $18,897,732 | 5,220,368 | Richard A. Miller | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.4% | $29,594,309 | 4,015,510 | BlackRock, Inc. | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 41,673,686 | $307,002,895 | +$4,353,875 | $7.37 | 101 |
| 2025 Q2 | 41,781,497 | $167,123,225 | +$27,653,733 | $4 | 92 |
| 2025 Q1 | 36,268,523 | $115,333,082 | -$7,370,970 | $3.18 | 87 |
| 2024 Q4 | 37,723,156 | $201,818,514 | +$34,704,752 | $5.35 | 85 |
| 2024 Q3 | 30,026,264 | $158,538,176 | +$12,733,385 | $5.28 | 61 |
| 2024 Q2 | 27,591,708 | $50,216,835 | +$17,655,345 | $1.82 | 46 |
| 2024 Q1 | 17,899,766 | $31,860,771 | -$2,279,392 | $1.78 | 46 |
| 2023 Q4 | 19,183,314 | $33,762,501 | +$90,871 | $1.76 | 46 |
| 2023 Q3 | 19,186,334 | $28,011,450 | -$1,230,958 | $1.46 | 52 |
| 2023 Q2 | 19,491,995 | $44,633,999 | +$707,708 | $2.29 | 51 |
| 2023 Q1 | 20,767,710 | $18,897,208 | -$183,902 | $0.91 | 35 |
| 2022 Q4 | 21,363,573 | $18,157,963 | -$606,364 | $0.85 | 38 |
| 2022 Q3 | 22,082,952 | $18,073,081 | -$3,458,421 | $0.8183 | 38 |
| 2022 Q2 | 25,594,950 | $25,339,212 | -$3,279,778 | $0.99 | 39 |
| 2022 Q1 | 27,387,121 | $44,913,000 | -$1,201,434 | $1.64 | 52 |
| 2021 Q4 | 27,678,421 | $66,701,000 | -$7,831,144 | $2.41 | 58 |
| 2021 Q3 | 28,180,241 | $136,388,000 | +$22,907,893 | $4.84 | 55 |
| 2021 Q2 | 23,673,230 | $63,207,000 | +$8,569,595 | $2.67 | 44 |
| 2021 Q1 | 20,393,400 | $62,807,000 | +$12,093,812 | $3.08 | 45 |
| 2020 Q4 | 16,311,910 | $58,071,014 | -$3,250,489 | $3.56 | 34 |
| 2020 Q3 | 17,216,699 | $69,036,016 | -$11,684,715 | $4.01 | 33 |
| 2020 Q2 | 20,440,680 | $55,598,011 | -$392,205 | $2.72 | 34 |
| 2020 Q1 | 20,651,240 | $43,573,167 | -$3,308,904 | $2.11 | 36 |
| 2019 Q4 | 20,779,789 | $113,038,430 | -$10,373,847 | $5.44 | 35 |
| 2019 Q3 | 22,891,685 | $68,903,436 | -$4,060,912 | $3.01 | 34 |
| 2019 Q2 | 24,342,578 | $90,952,754 | -$1,503,000 | $3.74 | 43 |
| 2019 Q1 | 24,763,106 | $99,529,635 | -$1,002,484 | $4.02 | 56 |
| 2018 Q4 | 25,129,757 | $92,163,767 | -$1,838,747 | $3.67 | 60 |
| 2018 Q3 | 25,496,765 | $218,762,586 | -$3,322,901 | $8.58 | 60 |
| 2018 Q2 | 25,906,899 | $284,454,314 | +$6,770,964 | $10.98 | 56 |
| 2018 Q1 | 25,285,587 | $287,758,705 | +$90,614,709 | $11.53 | 54 |
| 2017 Q4 | 17,418,578 | $180,457,571 | -$3,160,000 | $10.36 | 53 |
| 2017 Q3 | 17,544,055 | $279,715,086 | +$1,015,923 | $15.94 | 52 |
| 2017 Q2 | 17,504,516 | $211,804,598 | -$2,803,453 | $12.1 | 48 |
| 2017 Q1 | 17,335,240 | $360,050,125 | +$9,744,515 | $20.77 | 52 |
| 2016 Q4 | 17,484,501 | $250,048,615 | +$17,391,608 | $14.3 | 53 |
| 2016 Q3 | 16,266,787 | $267,555,203 | -$17,049,726 | $16.45 | 44 |
| 2016 Q2 | 14,645,573 | $208,464,147 | +$13,774,406 | $14.26 | 43 |
| 2016 Q1 | 13,758,120 | $199,086,000 | +$197,418,000 | $14.5 | 31 |