| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 9.99% | +1.9% | $60,117,785 | +$12,881,057 | 17,176,510 | +27.3% | TANG CAPITAL MANAGEMENT, LLC | 30 Sep 2025 |
| ORBIMED ADVISORS LLC | 8.9% | -19.1% | $41,093,984 | 15,219,994 | 0% | ORBIMED ADVISORS LLC | 13 Aug 2025 | |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8.2% | +60% | $44,559,662 | +$21,967,265 | 14,101,159 | +97.2% | Suvretta Capital Management, LLC | 13 Aug 2025 |
| Vivo Opportunity Fund Holdings, L.P. | 5.1% | $31,485,926 | 8,995,979 | Vivo Opportunity Fund Holdings, L.P. | 30 Sep 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 5.1% | $30,625,000 | 8,750,000 | BVF PARTNERS L P/IL | 22 Oct 2025 | |||
| Commander Aggregator, LP | 4.5% | $24,610,554 | 7,788,150 | Commander Aggregator, LP | 14 Aug 2025 | |||
| BlackRock, Inc. | 4.6% | -8% | $16,637,369 | -$1,270,430 | 6,398,988 | -7.1% | BlackRock, Inc. | 30 Jun 2025 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.36% | $11,629,931 | 5,994,810 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| MPM BioImpact LLC | 4.1% | -35% | $15,180,764 | -$7,952,556 | 5,622,505 | -34.4% | MPM BioImpact LLC | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 151,051,532 | $528,689,677 | +$149,915,944 | $3.5 | 123 |
| 2025 Q2 | 108,253,035 | $281,458,749 | +$738,261 | $2.6 | 103 |
| 2025 Q1 | 108,444,414 | $206,047,938 | +$13,824,994 | $1.9 | 107 |
| 2024 Q4 | 101,374,021 | $146,996,022 | +$1,180,763 | $1.45 | 92 |
| 2024 Q3 | 92,186,861 | $169,597,729 | +$881,089 | $1.84 | 79 |
| 2024 Q2 | 92,861,661 | $93,412,908 | -$5,271,746 | $1 | 81 |
| 2024 Q1 | 94,552,324 | $187,180,490 | +$18,089,983 | $1.98 | 77 |
| 2023 Q4 | 86,111,898 | $134,344,397 | -$2,317,455 | $1.56 | 76 |
| 2023 Q3 | 89,720,729 | $176,712,745 | -$1,697,948 | $1.97 | 76 |
| 2023 Q2 | 90,478,972 | $287,651,504 | +$28,216,829 | $3.18 | 72 |
| 2023 Q1 | 81,516,748 | $266,518,963 | +$1,871,389 | $3.27 | 72 |
| 2022 Q4 | 79,833,267 | $401,391,571 | +$78,919,542 | $5.03 | 54 |
| 2022 Q3 | 63,858,418 | $145,631,000 | +$3,917,942 | $2.28 | 36 |
| 2022 Q2 | 61,892,616 | $163,922,000 | +$665,806 | $2.65 | 31 |
| 2022 Q1 | 62,376,106 | $85,353,000 | -$4,074,753 | $1.37 | 33 |
| 2021 Q4 | 63,567,962 | $201,611,000 | +$198,091,000 | $3.17 | 37 |