| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $81.4M | 16.6M | FMR LLC | 31 Dec 2024 | |||
| Fairmount Funds Management LLC | 9.9% | 0% | $224M | $21.9M | 15.9M | +10.8% | Fairmount Funds Management LLC | 13 Nov 2025 |
| Commodore Capital LP | 7.2% | +28.3% | $147M | $54.6M | 10.2M | +59.3% | Commodore Capital LP | 30 Sep 2025 |
| Flynn James E | 6.49% | $65M | 9.05M | Deerfield Mgmt, L.P. | 07 Jul 2025 | |||
| Kynam Capital Management, LP | 5.54% | $113M | 7.89M | Kynam Capital Management, LP | 30 Sep 2025 | |||
| TCG Crossover GP I, LLC | 4.8% | $97.6M | 6.8M | TCG Crossover GP I, LLC | 30 Sep 2025 | |||
| Point72 Asset Management, L.P. | 4% | -52.2% | $82.6M | -$60.8M | 5.75M | -42.4% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| Venrock Healthcare Capital Partners II, L.P. | 4.2% | -26.7% | $44.5M | -$15.8M | 4.76M | -26.2% | Venrock Healthcare Capital Partners II, L.P. | 30 Jun 2025 |
| Paradigm Biocapital Advisors LP | 2.3% | -75.6% | $45.3M | -$103M | 3.16M | -69.5% | Paradigm BioCapital Advisors LP | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 159M | $2.29B | +$378M | $14.36 | 190 |
| 2025 Q2 | 136M | $973M | +$19M | $7.18 | 175 |
| 2025 Q1 | 133M | $800M | +$57.9M | $5.99 | 182 |
| 2024 Q4 | 122M | $949M | -$21.7M | $7.80 | 173 |
| 2024 Q3 | 122M | $1.32B | +$471K | $10.80 | 160 |
| 2024 Q2 | 121M | $1.02B | +$107M | $8.43 | 146 |
| 2024 Q1 | 109M | $734M | +$128M | $6.72 | 144 |
| 2023 Q4 | 90.8M | $534M | -$45.4M | $5.88 | 141 |
| 2023 Q3 | 90.9M | $886M | +$20.5M | $9.75 | 134 |
| 2023 Q2 | 88.5M | $1.05B | +$159M | $11.84 | 134 |
| 2023 Q1 | 75.2M | $810M | +$3.23M | $10.79 | 133 |
| 2022 Q4 | 74.7M | $863M | -$1.8M | $11.56 | 133 |
| 2022 Q3 | 73.7M | $1.1B | +$70.8M | $14.92 | 129 |
| 2022 Q2 | 70.1M | $632M | +$209M | $9.02 | 107 |
| 2022 Q1 | 47.2M | $354M | -$5.66M | $7.49 | 81 |
| 2021 Q4 | 44.9M | $385M | +$41.8M | $8.58 | 80 |
| 2021 Q3 | 36.8M | $310M | +$4.14M | $8.41 | 71 |
| 2021 Q2 | 35M | $284M | +$12.9M | $8.11 | 65 |
| 2021 Q1 | 34.4M | $303M | +$9.82M | $8.78 | 65 |
| 2020 Q4 | 33.5M | $376M | +$318M | $11.23 | 67 |