| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $81,355,047 | 16,569,256 | FMR LLC | 31 Dec 2024 | |||
| Fairmount Funds Management LLC | 9.9% | 0% | $224,347,916 | +$21,936,825 | 15,877,418 | +10.8% | Fairmount Funds Management LLC | 13 Nov 2025 |
| Commodore Capital LP | 7.2% | +28.3% | $146,587,742 | +$54,568,000 | 10,208,060 | +59.3% | Commodore Capital LP | 30 Sep 2025 |
| Flynn James E | 6.49% | $65,023,115 | 9,053,118 | Deerfield Mgmt, L.P. | 07 Jul 2025 | |||
| Kynam Capital Management, LP | 5.54% | $113,245,430 | 7,886,172 | Kynam Capital Management, LP | 30 Sep 2025 | |||
| TCG Crossover GP I, LLC | 4.8% | $97,621,606 | 6,798,162 | TCG Crossover GP I, LLC | 30 Sep 2025 | |||
| Point72 Asset Management, L.P. | 4% | -52.2% | $82,625,042 | -$60,775,814 | 5,753,833 | -42.4% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| Venrock Healthcare Capital Partners II, L.P. | 4.2% | -26.7% | $44,463,093 | -$15,815,581 | 4,755,411 | -26.2% | Venrock Healthcare Capital Partners II, L.P. | 30 Jun 2025 |
| Paradigm Biocapital Advisors LP | 2.3% | -75.6% | $45,325,875 | -$103,335,292 | 3,156,398 | -69.5% | Paradigm BioCapital Advisors LP | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 159,214,681 | $2,286,257,324 | +$377,674,083 | $14.36 | 190 |
| 2025 Q2 | 135,519,487 | $973,045,860 | +$18,987,122 | $7.18 | 175 |
| 2025 Q1 | 133,492,788 | $799,614,961 | +$57,857,622 | $5.99 | 182 |
| 2024 Q4 | 121,716,056 | $949,488,255 | -$21,661,319 | $7.8 | 173 |
| 2024 Q3 | 121,834,182 | $1,316,352,629 | +$470,587 | $10.8 | 160 |
| 2024 Q2 | 121,381,737 | $1,023,259,146 | +$106,597,224 | $8.43 | 146 |
| 2024 Q1 | 109,208,822 | $733,878,161 | +$128,257,287 | $6.72 | 144 |
| 2023 Q4 | 90,814,821 | $533,992,647 | -$45,403,172 | $5.88 | 141 |
| 2023 Q3 | 90,861,393 | $885,844,189 | +$20,538,646 | $9.75 | 134 |
| 2023 Q2 | 88,529,694 | $1,048,151,896 | +$158,614,636 | $11.84 | 134 |
| 2023 Q1 | 75,176,767 | $810,346,243 | +$3,226,883 | $10.79 | 133 |
| 2022 Q4 | 74,675,712 | $863,268,307 | -$1,804,375 | $11.56 | 133 |
| 2022 Q3 | 73,734,143 | $1,100,096,408 | +$70,755,840 | $14.92 | 129 |
| 2022 Q2 | 70,081,829 | $632,136,824 | +$209,072,563 | $9.02 | 107 |
| 2022 Q1 | 47,217,562 | $353,580,440 | -$5,659,624 | $7.49 | 81 |
| 2021 Q4 | 44,899,168 | $385,164,997 | +$41,807,073 | $8.58 | 80 |
| 2021 Q3 | 36,797,124 | $309,606,147 | +$4,142,169 | $8.41 | 71 |
| 2021 Q2 | 34,971,040 | $283,623,000 | +$12,872,399 | $8.11 | 65 |
| 2021 Q1 | 34,431,767 | $303,253,000 | +$9,820,126 | $8.78 | 65 |
| 2020 Q4 | 33,524,756 | $376,481,000 | +$318,450,000 | $11.23 | 67 |