Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2015 to Q3 2025

Type / Class: Equity / Common Stock, par value $0.001 per share
Symbol: BPMC
Shares outstanding: 65,000,000
Price per share: $128.79
All holders as of 30 Sep 2025: Q3 2025
Total 13F shares: 26,105
Total reported value: $2,576,619
% of total 13F portfolios: 0%
Share change: -64,211,585
Value change: -$8,230,672,864
Number of holders: 5
Price from insider filings: $128.79

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC) based on Schedule 13D/G filings

Filer	Ownership	Change %	Holdings Value	Net Change	Nb Shares	Change %	Reporting Name	Report Period
BlackRock, Inc.	8%		$438,260,343		5,090,723		BlackRock, Inc.	31 Mar 2025
Pentwater Capital Management LP	6%		$501,345,000		3,900,000		Pentwater Capital Management LP	30 Jun 2025
WELLINGTON MANAGEMENT GROUP LLP	4.8%		$264,580,914		3,073,306		Wellington Management Group LLP	31 Mar 2025
FMR LLC	3.5%		$193,502,643		2,247,679		FMR LLC	31 Dec 2024
PRICE T ROWE ASSOCIATES INC /MD/	2.3%		$188,330,378		1,465,036		T. Rowe Price Associates, Inc.	30 Jun 2025
Avoro Capital Advisors LLC	0.6%	-90%	$48,206,250	-$446,711,250	375,000	-90%	Avoro Capital Advisors LLC	30 Jun 2025

As of 30 Sep 2025, 5 institutional investors reported holding 26,105 shares of Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC). This represents 0.04% of the company’s total 65,000,000 outstanding shares.

Institutional Holders of Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC) across Reporting Periods

Period	Reported Shares, Excl. Options	Value, Excl. Options	Value Change	Puts Notional Value	Calls Notional Value	Price (Median)	Investors
2025 Q3	26,105	$2,576,619	-$8,230,672,864	$0	$0	$128.79	5
2025 Q2	64,312,805	$8,243,642,810	-$128,604,537	$195,692,406	$124,720,586	$128.18	351
2025 Q1	68,515,184	$6,063,993,897	+$140,099,025	$93,236,700	$136,597,483	$88.51	348
2024 Q4	67,115,861	$5,854,192,362	+$126,899,926	$121,325,782	$139,304,544	$87.22	336
2024 Q3	65,318,958	$6,043,433,303	-$164,062,764	$109,095,055	$208,023,655	$92.50	315
2024 Q2	66,328,149	$7,149,236,804	+$48,438,893	$60,184,352	$114,419,616	$107.78	302
2024 Q1	65,816,848	$6,243,787,913	+$177,301,995	$65,519,468	$67,284,244	$94.86	278
2023 Q4	64,072,815	$5,910,035,943	-$46,573,724	$52,770,600	$73,312,448	$92.24	255
2023 Q3	64,715,958	$3,250,100,220	+$14,323,141	$22,332,834	$7,859,430	$50.22	217
2023 Q2	63,590,792	$4,019,089,438	+$55,157,380	$24,496,320	$9,435,760	$63.20	216
2023 Q1	63,289,977	$2,844,730,700	+$37,372,534	$15,138,700	$6,492,057	$44.99	211
2022 Q4	62,710,123	$2,747,307,504	-$81,340,704	$9,817,675	$5,690,919	$43.81	217
2022 Q3	63,026,048	$4,152,774,974	-$128,845,752	$8,527,000	$14,884,000	$65.89	225
2022 Q2	63,150,127	$3,190,446,271	+$153,165,037	$9,436,000	$21,794,000	$50.51	217
2022 Q1	59,787,423	$3,819,690,831	-$49,008,451	$6,587,000	$11,311,000	$63.88	230
2021 Q4	58,954,217	$6,315,932,336	-$30,886,672	$9,950,000	$6,309,000	$107.11	268
2021 Q3	59,635,260	$6,131,078,115	+$116,842,275	$16,912,000	$36,605,000	$102.81	277
2021 Q2	58,476,330	$5,143,894,117	-$35,068,728	$12,790,000	$8,505,000	$87.96	271
2021 Q1	58,503,342	$5,692,147,794	+$110,589,775	$15,955,000	$6,787,000	$97.23	253
2020 Q4	57,620,842	$6,462,000,707	+$68,838,444	$54,233,965	$19,817,405	$112.15	271
2020 Q3	56,891,234	$5,271,748,149	+$134,477,194	$19,273,000	$21,475,000	$92.70	233
2020 Q2	56,241,583	$4,386,082,844	+$150,414,585	$53,002,000	$37,222,000	$78.00	227
2020 Q1	54,500,343	$3,186,566,973	+$193,923,003	$26,216,000	$28,597,000	$58.48	203
2019 Q4	50,739,129	$4,064,646,435	-$62,842,415	$51,623,000	$34,479,000	$80.11	221
2019 Q3	51,436,764	$3,779,091,159	+$139,996,789	$27,905,000	$82,461,000	$73.47	212
2019 Q2	49,572,751	$4,675,884,768	+$324,726,215	$33,082,000	$55,957,000	$94.33	217
2019 Q1	48,530,965	$3,884,677,938	+$226,884,588	$16,779,000	$14,160,000	$80.05	200
2018 Q4	45,667,665	$2,458,997,783	-$75,489,962	$6,022,000	$7,746,000	$53.91	157
2018 Q3	44,853,567	$3,501,103,825	+$29,002,258	$16,456,000	$9,680,000	$78.06	186
2018 Q2	44,815,573	$2,844,822,168	+$140,175,140	$17,114,000	$33,371,000	$63.48	177
2018 Q1	41,175,457	$3,775,678,943	+$79,685,163	$13,736,000	$13,554,000	$91.70	173
2017 Q4	42,824,142	$3,229,416,996	+$311,339,150	$5,550,000	$18,249,000	$75.41	166
2017 Q3	36,265,378	$2,526,591,713	+$26,629,111	$2,627,000	$3,444,000	$69.67	134
2017 Q2	35,562,415	$1,801,945,033	+$78,990,151	$4,256,000	$2,730,000	$50.67	123
2017 Q1	34,688,336	$1,387,181,269	+$416,751,429	$1,806,000	$2,812,000	$39.99	133
2016 Q4	26,029,473	$730,115,893	+$172,572,667	$363,000	$348,000	$28.05	101
2016 Q3	19,170,288	$569,347,585	+$16,106,841	$276,000	$293,000	$29.70	87
2016 Q2	19,506,647	$394,921,156	+$32,946,791		$0	$20.25	82
2016 Q1	17,896,943	$323,004,000	-$4,071,216		$5,957,000	$18.05	70
2015 Q4	17,994,524	$473,980,234	+$22,327,835		$11,477,000	$26.34	72
2015 Q3	23,905,839	$509,238,942	+$16,095,105			$21.34	70
2015 Q2	23,164,184	$611,154,430	+$610,026,412			$26.49	70