| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Medine GmbH | 18% | $4,386,515,536 | 42,178,034 | Prof. Ugur Sahin, M.D. | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BAILLIE GIFFORD & CO | 3.3% | 7,879,359 | -2% | 0.58% | $777,062,385 |
| FMR LLC | 2.3% | 5,453,480 | -33% | 0.03% | $537,822,188 |
| T. Rowe Price Investment Management, Inc. | 2% | 4,833,642 | +34% | 0.29% | $476,694,000 |
| FLOSSBACH VON STORCH SE | 1.8% | 4,230,033 | -0% | 1.6% | $417,165,854 |
| PRIMECAP MANAGEMENT CO/CA/ | 1.6% | 3,870,766 | -3.3% | 0.29% | $381,734,943 |
| Dodge & Cox | 1.5% | 3,647,091 | +316% | 0.19% | $359,676,114 |
| Pfizer Inc | 0.69% | 1,658,361 | -55% | 37% | $163,547,562 |
| Temasek Holdings (Private) Ltd | 0.63% | 1,506,027 | 0% | 0.52% | $148,524,383 |
| Capital International Investors | 0.47% | 1,135,066 | +0.14% | 0.02% | $111,940,209 |
| BNP PARIBAS FINANCIAL MARKETS | 0.46% | 1,103,298 | 0% | 0.08% | $108,807,249 |
| BlackRock, Inc. | 0.32% | 765,309 | -42% | 0% | $75,474,736 |
| FRANKLIN RESOURCES INC | 0.31% | 732,816 | -2.6% | 0.02% | $72,270,267 |
| UBS Group AG | 0.25% | 607,440 | +135% | 0.01% | $59,905,733 |
| MORGAN STANLEY | 0.25% | 603,016 | +4.9% | 0% | $59,469,525 |
| Candriam S.C.A. | 0.25% | 589,452 | +0.46% | 0.31% | $58,131,756 |
| BANK OF AMERICA CORP /DE/ | 0.24% | 573,356 | +344% | 0% | $56,544,369 |
| Bank of New York Mellon Corp | 0.24% | 568,707 | -49% | 0.01% | $56,085,873 |
| DekaBank Deutsche Girozentrale | 0.2% | 481,397 | 0% | 0.08% | $47,230,000 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0.19% | 459,673 | -6.6% | 0.04% | $45,301,241 |
| VICTORY CAPITAL MANAGEMENT INC | 0.17% | 413,685 | +97% | 0.02% | $37,530,850 |
| Long Focus Capital Management, LLC | 0.17% | 397,655 | +91% | 2.3% | $39,216,736 |
| CITADEL ADVISORS LLC | 0.16% | 389,495 | +14262% | 0.03% | $38,411,997 |
| DEUTSCHE BANK AG\ | 0.16% | 382,476 | +11% | 0.01% | $37,719,784 |
| BAKER BROS. ADVISORS LP | 0.15% | 368,923 | 0% | 0.26% | $36,383,186 |
| LBP AM SA | 0.15% | 353,329 | +16% | 0.43% | $34,845,306 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 398,125 | $37,901,798 | +$32,836,993 | $95.20 | 4 |
| 2025 Q3 | 50,457,110 | $4,972,006,484 | -$321,044,592 | $98.62 | 252 |
| 2025 Q2 | 53,756,637 | $5,723,405,583 | +$241,986,249 | $106.47 | 255 |
| 2025 Q1 | 51,766,102 | $4,713,883,792 | +$16,375,983 | $91.06 | 276 |
| 2024 Q4 | 50,762,221 | $5,785,970,647 | +$270,315,091 | $113.95 | 299 |
| 2024 Q3 | 44,146,673 | $5,240,957,854 | +$448,042,220 | $118.77 | 288 |
| 2024 Q2 | 40,965,872 | $3,292,084,415 | -$3,371,001 | $80.36 | 278 |
| 2024 Q1 | 40,861,236 | $3,768,152,227 | +$21,661,779 | $92.25 | 278 |
| 2023 Q4 | 40,542,745 | $4,273,885,983 | +$369,420,974 | $105.54 | 277 |
| 2023 Q3 | 36,919,967 | $4,008,689,944 | -$40,677,233 | $108.64 | 245 |
| 2023 Q2 | 37,381,433 | $4,042,183,779 | -$207,319,966 | $107.93 | 246 |
| 2023 Q1 | 39,079,137 | $4,865,003,807 | -$130,605,071 | $124.57 | 272 |
| 2022 Q4 | 39,706,670 | $5,966,384,929 | +$387,882,980 | $150.22 | 312 |
| 2022 Q3 | 37,131,368 | $5,008,892,299 | +$489,942,648 | $134.88 | 249 |
| 2022 Q2 | 33,416,255 | $4,980,080,985 | -$212,346,370 | $149.10 | 276 |
| 2022 Q1 | 34,519,697 | $5,890,695,868 | -$225,320,254 | $170.56 | 274 |
| 2021 Q4 | 35,195,775 | $9,066,882,359 | -$433,429,701 | $257.80 | 334 |
| 2021 Q3 | 36,667,998 | $10,011,251,135 | +$781,975,407 | $272.99 | 328 |
| 2021 Q2 | 33,709,299 | $7,548,281,316 | +$1,380,454,495 | $223.88 | 275 |
| 2021 Q1 | 29,716,757 | $3,242,039,601 | +$922,839,812 | $109.19 | 213 |
| 2020 Q4 | 20,695,182 | $1,688,417,367 | -$282,174,671 | $81.52 | 183 |
| 2020 Q3 | 24,274,421 | $1,679,824,791 | -$160,429,955 | $69.23 | 144 |
| 2020 Q2 | 26,613,030 | $1,776,088,789 | +$1,335,873,540 | $66.74 | 108 |
| 2020 Q1 | 6,620,182 | $383,744,138 | -$108,916,451 | $58.40 | 36 |
| 2019 Q4 | 8,476,761 | $285,550,000 | +$285,550,000 | $33.88 | 19 |