AYTU BIOPHARMA, INC - Common Stock (AYTU) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2023 to Q4 2025

Type / Class
Equity / Common Stock
Symbol
AYTU on Nasdaq
Shares outstanding
10,876,096
Price per share
$2.59
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
3,580,253
Total reported value
$6,730,606
% of total 13F portfolios
0%
Share change
+164,077
Value change
+$120,543
Number of holders
31
Price from insider filings
$2.59
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of AYTU BIOPHARMA, INC - Common Stock (AYTU) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Nantahala Capital Management, LLC 14% $1,423,724 1,086,812 Nantahala Capital Management, LLC 06 Jun 2025
LYTTON LAURENCE W 10% +73% $2,173,044 +$1,159,834 1,086,522 +114% LYTTON LAURENCE W 30 Sep 2025
Stonepine Capital Management, LLC 9.9% $1,975,217 906,063 Stonepine Capital Management, LLC 30 Jun 2025

As of 30 Sep 2025, 31 institutional investors reported holding 3,580,253 shares of AYTU BIOPHARMA, INC - Common Stock (AYTU). This represents 33% of the company’s total 10,876,096 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of AYTU BIOPHARMA, INC - Common Stock (AYTU) together control 33% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
Nantahala Capital Management, LLC 10% 1,086,812 0% 0.13% $2,043,207
Stonepine Capital Management, LLC 8.2% 891,855 +9.7% 1.4% $1,676,687
AWM Investment Company, Inc. 5.7% 619,574 -0.05% 0.11% $1,164,799
VANGUARD GROUP INC 2.6% 278,583 +899% 0% $523,736
DIADEMA PARTNERS LP 2.5% 272,670 0.36% $512,620
RENAISSANCE TECHNOLOGIES LLC 0.87% 95,123 +5.8% 0% $178,831
GEODE CAPITAL MANAGEMENT, LLC 0.65% 71,006 +32% 0% $133,516
TWO SIGMA INVESTMENTS, LP 0.63% 68,736 +96% 0% $129,224
Persistent Asset Partners Ltd 0.57% 62,452 0.09% $117,410
TWO SIGMA ADVISERS, LP 0.37% 39,800 0% $74,824
DIMENSIONAL FUND ADVISORS LP 0.28% 30,964 0% $58,213
BlackRock, Inc. 0.21% 22,793 0% 0% $42,851
Jaffetilchin Investment Partners, LLC 0.16% 17,437 0% 0% $32,782
ACADIAN ASSET MANAGEMENT LLC 0.09% 10,237 0% 0% $19,000
Tower Research Capital LLC (TRC) 0.04% 4,323 +70% 0% $8,127
MAI Capital Management 0.03% 3,575 0% 0% $6,721
UBS Group AG 0.03% 3,135 +2.9% 0% $5,895
OSAIC HOLDINGS, INC. 0% 455 +52% 0% $803
MORGAN STANLEY 0% 286 0% 0% $538
WELLS FARGO & COMPANY/MN 0% 127 0% 0% $239
CIBC Private Wealth Group LLC 0% 83 0% 0% $156
BANK OF AMERICA CORP /DE/ 0% 74 +17% 0% $139
SBI Securities Co., Ltd. 0% 62 -71% 0% $117
GROUP ONE TRADING LLC 0% 37 0% 0% $70
BNP PARIBAS FINANCIAL MARKETS 0% 23 0% 0% $43

Institutional Holders of AYTU BIOPHARMA, INC - Common Stock (AYTU) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 31,600 $82,000 +$49,218 $2.59 1
2025 Q3 3,580,253 $6,730,606 +$120,543 $1.88 31
2025 Q2 3,416,181 $7,446,105 +$3,456,447 $2.18 30
2025 Q1 1,876,606 $2,489,917 +$8,023 $1.20 29
2024 Q4 1,880,741 $3,193,340 -$294,695 $1.70 28
2024 Q3 2,048,299 $4,813,170 -$27,368 $2.35 23
2024 Q2 2,053,775 $5,994,953 +$752,481 $2.92 26
2024 Q1 1,795,464 $5,457,735 +$79,751 $3.04 26
2023 Q4 1,769,256 $5,024,294 +$125,688 $2.84 21
2023 Q3 1,724,718 $4,655,967 +$78,103 $2.70 20
2023 Q2 1,704,120 $2,726,370 +$1,773,284 $1.60 19
2023 Q1 540,753 $1,211,630 +$1,211,205 $2.24 18