| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Matrix Capital Management Company, LP | 11% | $38,214,242 | 6,922,870 | Matrix Capital Management Company LP | 16 May 2025 | |||
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7.6% | +25% | $30,091,360 | +$10,524,518 | 4,701,775 | +54% | Suvretta Capital Management, LLC | 30 Jun 2025 |
| BlackRock, Inc. | 5.4% | +10% | $20,617,314 | +$1,842,342 | 3,336,027 | +9.8% | BlackRock, Inc. | 30 Sep 2025 |
| Long Focus Capital Management, LLC | 6.6% | +75% | $18,324,093 | +$4,481,180 | 3,319,582 | +32% | LONG FOCUS CAPITAL MANAGEMENT, LLC | 31 Mar 2025 |
| Frazier Life Sciences Public Fund, L.P. | 5% | -49% | $19,926,720 | -$20,493,619 | 3,113,550 | -51% | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Matrix Capital Management Company, LP | 11% | 6,922,870 | 0% | 40% | $42,783,337 |
| Frazier Life Sciences Management, L.P. | 8.3% | 5,100,000 | 0% | 0.94% | $31,518,000 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7.9% | 4,881,125 | 0% | 0.05% | $30,165,353 |
| Long Focus Capital Management, LLC | 7.5% | 4,619,582 | 0% | 1.7% | $28,549,017 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7.1% | 4,372,884 | 0% | 0.82% | $27,024,423 |
| BlackRock, Inc. | 5.5% | 3,405,477 | +9.8% | 0% | $21,045,849 |
| Medicxi Ventures Management (Jersey) Ltd | 4.9% | 3,039,892 | 0% | 2.5% | $18,786,533 |
| VANGUARD GROUP INC | 4.7% | 2,890,503 | +17% | 0% | $17,863,309 |
| FRANKLIN RESOURCES INC | 3.6% | 2,198,915 | -6.1% | 0% | $13,589,295 |
| Nantahala Capital Management, LLC | 3.4% | 2,117,697 | 0% | 0.81% | $13,087,367 |
| LEVIN CAPITAL STRATEGIES, L.P. | 2.6% | 1,627,274 | +8.8% | 0.92% | $10,056,553 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 1,257,947 | +35% | 0% | $7,775,353 |
| UBS Group AG | 1.5% | 896,811 | +0.65% | 0% | $5,542,292 |
| STATE STREET CORP | 1.4% | 878,871 | +2.6% | 0% | $5,431,423 |
| Regency Capital Management Inc.\DE | 0.99% | 612,689 | -8% | 1.8% | $3,786,418 |
| ACORN CAPITAL ADVISORS, LLC | 0.96% | 595,744 | 0% | 1.9% | $3,681,698 |
| SAMSARA BIOCAPITAL, LLC | 0.95% | 584,849 | -42% | 0.47% | $3,614,367 |
| B Group, Inc. | 0.93% | 572,576 | 0% | 3.4% | $3,538,520 |
| Decheng Capital LLC | 0.83% | 515,555 | 0% | 0.56% | $3,186,130 |
| DIMENSIONAL FUND ADVISORS LP | 0.8% | 497,275 | +9% | 0% | $3,073,114 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0.78% | 481,231 | -4.7% | 0% | $2,975,000 |
| NORTHERN TRUST CORP | 0.7% | 433,641 | +17% | 0% | $2,679,902 |
| Caligan Partners LP | 0.37% | 227,174 | +14% | 0.19% | $1,403,935 |
| GOLDMAN SACHS GROUP INC | 0.32% | 194,943 | -8.2% | 0% | $1,204,748 |
| MILLENNIUM MANAGEMENT LLC | 0.3% | 185,221 | +49% | 0% | $1,144,666 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 88,422 | $478,500 | -$391,108 | $5.44 | 4 |
| 2025 Q3 | 51,649,515 | $319,192,253 | +$6,254,101 | $6.18 | 105 |
| 2025 Q2 | 50,616,053 | $316,863,119 | +$67,408,487 | $6.26 | 102 |
| 2025 Q1 | 39,264,901 | $230,096,030 | -$11,860,142 | $5.86 | 91 |
| 2024 Q4 | 39,449,434 | $324,276,778 | +$16,157,250 | $8.22 | 93 |
| 2024 Q3 | 36,866,668 | $329,191,609 | -$25,783,402 | $8.91 | 81 |
| 2024 Q2 | 39,765,227 | $300,437,451 | +$3,314,060 | $7.56 | 75 |
| 2024 Q1 | 39,115,323 | $307,072,789 | +$16,222,241 | $7.85 | 77 |
| 2023 Q4 | 36,998,812 | $327,811,496 | +$89,731,106 | $8.86 | 71 |
| 2023 Q3 | 26,323,010 | $236,119,190 | -$5,574,466 | $8.97 | 62 |
| 2023 Q2 | 27,066,492 | $334,426,517 | +$24,980,886 | $12.35 | 59 |
| 2023 Q1 | 25,069,599 | $232,645,346 | +$10,922,124 | $9.28 | 57 |
| 2022 Q4 | 23,806,818 | $250,037,016 | +$78,469,205 | $10.50 | 49 |
| 2022 Q3 | 16,317,002 | $295,663,462 | +$9,714,465 | $18.12 | 43 |
| 2022 Q2 | 15,793,428 | $223,796,376 | +$29,644,466 | $14.17 | 42 |
| 2022 Q1 | 13,702,730 | $298,756,000 | +$9,092,301 | $22.00 | 34 |
| 2021 Q4 | 13,081,587 | $220,131,000 | +$220,131,000 | $16.98 | 32 |